Drug Discovery Assisted by Kinetic Target Guided Synthesis

被引：0
|
作者：
Matsumaru, Takanori
机构：
来源：
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2015年 / 73卷 / 12期
关键词：
D O I：
10.5059/yukigoseikyokaishi.73.1245
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One of the modern medicinal chemistry methods is kinetic target-guided synthesis, where fragment molecules are interacted with a target protein and those in close proximity on the protein spontaneously cross-link by forming a covalent bond. The reactions, which is applicable to the kinetic target-guided synthesis proceed in water and are required no additional reagent. Here, several examples of kinetic target-guided synthesis are described.
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收藏
页码：1245 / 1246
页数：2
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