Copper-catalyzed oxidative benzylic C(sp3)-H amination: direct synthesis of benzylic carbamates

被引：23

作者：

Liu, Shuai ^{[1
]}

Achou, Raphael ^{[1
]}

Boulanger, Coline ^{[1
]}

Pawar, Govind ^{[1
]}

Kumar, Nivesh ^{[1
]}

Lusseau, Jonathan ^{[1
]}

Robert, Frederic ^{[1
]}

Landais, Yannick ^{[1
]}

机构：

[1] Univ Bordeaux, Inst Mol Sci ISM, UMR CNRS 5255, 351 Cours Liberat, F-33405 Talence, France

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 85期

关键词：

C-H AMINATION; CARBON-DIOXIDE; BOND FUNCTIONALIZATION; N-TOSYLHYDRAZONES; AMINES; DESIGN; UREAS; MILD; ISOCYANATES; MOLECULES;

D O I：

10.1039/d0cc05226d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new efficient strategy to access benzylic carbamates through C-H activation is reported. The use of a catalytic amount of a Cu(i)/diimine ligand in combination with NFSI ((PhSO2)(2)NF) or F-TEDA-PF6 as oxidants and H2NCO2R as an amine source directly leads to the C-N bond formation at the benzylic position. The mild reaction conditions and the broad substrate scope make this transformation a useful method for the late-stage incorporation of a ubiquitous carbamate fragment onto hydrocarbons.

引用

页码：13013 / 13016

页数：4

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