INFLUENCE OF THE ZEARALENONE ON THE ACTIVITY OF CHOSEN LIVER ENZYMES IN A RAT

Zearalenone is a mycotoxin compound produced mainly by Fusarium species of fungi which is present in cereals cultivated all over the world. The aim of the research was to examine the toxic influence of different doses of zearalenone on liver cells through estimating mycotoxin influence Oil markers evaluation of biochemical liver damage. The research was carried out on male Wistar rats. The rats were divided into 9 groups of 10 animals each. Group A was orally given 8% ethyl alcohol. Group 13, C, D, E was Orally given once a day for 10 days a zearalenone alcohol solution properly in dose of 50, 100, 200, 500 mu g/kg b.w. Single doses of zearalenone was given to the animals front groups, X, Y, Z and W. Control group W - 8% ethyl alcohol, group X dose I mg/kg b.w., group Y dose 2 mg/kg b.w., group Z dose 3 mg/kg b.w. For the research. blood was taken from hearts. The blood was centrifuged and the plasma analyzed Using spectrophotometric methods: aspartate and alanine aminotransferase, alkaline phosphatase and complete bilirubine. The results of the experiment show that liver cells are exposed to zearalenon activity increased liver aminotransferases (ALT and AST) in blood plasma. Rise of liver aminotransferase level (ALT and AST) in animal's blood plasma after giving zearalenon may confirm the hepatotoxic influence of this mycotoxin. Short-lasting zearalenone influence does not cause changes in the liver aminotransferases.