Paying hypertension research subjects - Fair compensation or undue inducement?

CONTEXT: Cash payments are often used to compensate subjects who participate in research. However, ethicists have argued that these payments might constitute an undue inducement. OBJECTIVES: To determine whether potential subjects agree with theoretical arguments that a payment could be an undue inducement. DESIGN/SETTING/PARTICIPANTS: Survey of 350 prospective jurors. MAIN OUTCOME MEASURES: Belief that a $500 payment for research participation would Impair their own, and others' ability to think carefully about the risks and benefits of a clinical trial. RESULTS: Two hundred sixty-one jurors (74.6%) believed that a $500 payment would impair subjects' ability to think carefully about the risks and benefits of research. Ninety-six of 120 (80%) expressed this concern about subjects with a low Income (<$20,000) compared to 92/117 (79%) of those with a middle income ($20,000 to $50,000). and 73/113 (65%) with a high Income (>$50,000). In contrast, only 69 (19.7%) of jurors believed that a $500 payment would influence them. Jurors who believed that this payment would Influence them reported lower Incomes and less education. CONCLUSION: Members of the general public share ethical concerns about the Influence of payments for research, although they believe that these concerns are more applicable to others than to themselves.