Menopause influences aortic pulse pressure and pressure wave responses to metaboreflex activation in women

Objective: Postmenopausal women (post-MW) have greater risk of heart failure due to aortic pulsatile overload on the left ventricle associated with increased backward wave pressure (Pb). Post-MW have exaggerated peripheral blood pressure (BP) response to exercise mediated by metaboreflex (postexercise muscle ischemia [PEMI]) overactivation. Increased forward wave pressure (Pf) and Pb are determinants of aortic pulse pressure (PP) during isometric handgrip exercis (IHG) in young adults. We hypothesized that aortic PP and pressure wave responses to PEMI are augmented in nonhypertensive post-MW compared with premenopausal women (pre-MW). Methods: Aortic BP, Pf, Pb, and reflectionmagnitudewere assessed at rest and during IHG and PEMI by applanation tonometry in 15 pre-MWand 16 post-MW. Results: Aortic systolic BP during PEMI similarly increased in both groups. The increase in diastolic BP was lower in post-MW(post-MW Delta 6 +/- 2 vs pre-MW Delta 11 +/- 2 mm Hg, P < 0.05). Aortic PP (post-MW Delta 8 +/- 2 vs pre-MW Delta 3 +/- 2), Pf (post-MW Delta 6 +/- 1 vs pre-MW Delta 0 +/- 1), and Pb (post-MW Delta 5 +/- 1 vs pre-MW Delta 2 +/- 1) augmented during PEMI in post-MW (P < 0.05 for all), but not in pre-MW. Reflection magnitude increased during PEMI only in pre-MW (pre-MW Delta 7 +/- 2 vs post-MW Delta-1 +/- 2, P < 0.05) due to concurrent increases in Pf and Pb in post-MW. Conclusions: Even in nonhypertensive postmenopausal women, increases in Pf and Pb and decrease in aortic DBP are important factors that contribute to the augmented aortic PP response to PEMI.