Major depressive disorder (MDD) is characterized by biased information processing that leads to difficulties regulating negative affect, which includes difficulty decreasing negative affect as well as maladaptively increasing negative affect via cognitive processes. To examine the underlying neural correlates, we scanned depressed and never-depressed adults as they completed a cognitive reappraisal task which required decreasing negative affect while viewing a negative image (down-regulation) and increasing negative affect while viewing a neutral image (emotion generation). Compared to control participants, MDD participants had less recruitment of the dorsal anterior cingulate (dACC) and supplementary motor area (SMA) during early phases of down-regulation, the latter associated with poorer negative affect regulation. Further, MDD participants exhibited greater recruitment of the right middle temporal gyrus (MTG) during emotion generation, which was associated with lower negative affect. Dysregulated negative affect in MDD may be due to impairments in efficiently activating the dACC and SMA to meet regulation demands, and maladaptive generation of negative affect that characterizes individuals with MDD may be counteracted by compensatory activation in the MTG. Elucidating neural mechanisms that underlie the generation of negative affect in the absence of external stimuli is an important extension of previous work examining dysfunctional emotional processes in MDD.
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Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R ChinaUniv Calif San Diego, San Diego, CA 92103 USA
Liu, Jiangang
Li, Jun
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Xidian Univ, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R ChinaUniv Calif San Diego, San Diego, CA 92103 USA
Li, Jun
Zhang, Hongchuan
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Northwestern Univ, Evanston, IL 60208 USAUniv Calif San Diego, San Diego, CA 92103 USA
Zhang, Hongchuan
Rieth, Cory A.
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Univ Calif San Diego, San Diego, CA 92103 USAUniv Calif San Diego, San Diego, CA 92103 USA
Rieth, Cory A.
Huber, David E.
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Univ Calif San Diego, San Diego, CA 92103 USAUniv Calif San Diego, San Diego, CA 92103 USA
Huber, David E.
Li, Wu
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Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R ChinaUniv Calif San Diego, San Diego, CA 92103 USA
Li, Wu
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机构:
Lee, Kang
Tian, Jie
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机构:
Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
Xidian Univ, Life Sci Res Ctr, Xian 710071, Shaanxi, Peoples R ChinaUniv Calif San Diego, San Diego, CA 92103 USA