Neural correlates of top-down regulation and generation of negative affect in major depressive disorder

被引:18
|
作者
Davis, Elena Goetz [1 ,2 ]
Foland-Ross, Lara C. [1 ]
Gotlib, Ian H. [2 ]
机构
[1] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Psychol, Jordan Hall, Stanford, CA 94305 USA
关键词
Depression; Emotion regulation; Negative affect; Dorsal anterior cingulate; Supplementary motor area; Middle temporal gyrus; COGNITIVE EMOTION REGULATION; AMYGDALA ACTIVITY; FMRI; VULNERABILITY; METAANALYSIS; INFORMATION; SUPPRESSION; CIRCUITRY; RESPONSES; NETWORK;
D O I
10.1016/j.pscychresns.2018.04.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Major depressive disorder (MDD) is characterized by biased information processing that leads to difficulties regulating negative affect, which includes difficulty decreasing negative affect as well as maladaptively increasing negative affect via cognitive processes. To examine the underlying neural correlates, we scanned depressed and never-depressed adults as they completed a cognitive reappraisal task which required decreasing negative affect while viewing a negative image (down-regulation) and increasing negative affect while viewing a neutral image (emotion generation). Compared to control participants, MDD participants had less recruitment of the dorsal anterior cingulate (dACC) and supplementary motor area (SMA) during early phases of down-regulation, the latter associated with poorer negative affect regulation. Further, MDD participants exhibited greater recruitment of the right middle temporal gyrus (MTG) during emotion generation, which was associated with lower negative affect. Dysregulated negative affect in MDD may be due to impairments in efficiently activating the dACC and SMA to meet regulation demands, and maladaptive generation of negative affect that characterizes individuals with MDD may be counteracted by compensatory activation in the MTG. Elucidating neural mechanisms that underlie the generation of negative affect in the absence of external stimuli is an important extension of previous work examining dysfunctional emotional processes in MDD.
引用
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页码:1 / 8
页数:8
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