Site-Specific Clinical Evaluation of the Luminex xTAG Gastrointestinal Pathogen Panel for Detection of Infectious Gastroenteritis in Fecal Specimens

被引：41
|
作者：
Patel, Anami [1 ]
Navidad, Jose [2 ]
Bhattacharyya, Sanjib [2 ]
机构：
[1] Le Bonheur Childrens Hosp, Memphis, TN USA
[2] City Milwaukee Hlth Dept Lab, Milwaukee, WI 53202 USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2014年 / 52卷 / 08期
关键词：
UNITED-STATES; TIME; PCR; QUANTIFICATION; OUTBREAKS; BACTERIA; VIRUSES; IMPACT; ASSAY;
D O I：
10.1128/JCM.01393-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluate the clinical performance of the Luminex xTAG gastrointestinal (GI) pathogen in vitro diagnostic (IVD) assay in a comparison between clinical and public health laboratories. The site reproducibility study showed 98.7% sensitivity with high positive and negative agreement values (96.2% and 99.8%, respectively), while assay performance against confirmatory methods resulted in 96.4% sensitivity with similar positive and negative agreement values (90.1% and 99.5%, respectively). High-throughput detection of multiple GI pathogens improved turnaround time, consolidated laboratory workflow, and simplified stool culture practices, thus reducing the overall cost and number of specimens processed.
引用
收藏
页码：3068 / 3071
页数：4
相关论文
共 25 条
  • [1] A cost benefit analysis of the Luminex xTAG Gastrointestinal Pathogen Panel for detection of infectious gastroenteritis in hospitalised patients
    Goldenberg, Simon D.
    Bacelar, Mariana
    Brazier, Peter
    Bisnauthsing, Karen
    Edgeworth, Jonathan D.
    JOURNAL OF INFECTION, 2015, 70 (05) : 504 - 511
  • [2] Evaluation of Luminex xTAG Gastrointestinal Pathogen Panel Assay for Detection of Multiple Diarrheal Pathogens in Fecal Samples in Vietnam
    Vu Thuy Duong
    Voong Vinh Phat
    Ha Thanh Tuyen
    Tran Thi Ngoc Dung
    Pham Duc Trung
    Pham Van Minh
    Le Thi Phuong Tu
    Campbell, James I.
    Hoang Le Phuc
    Ton Thi Thanh Ha
    Nguyen Minh Ngoc
    Nguyen Thi Thanh Huong
    Pham Thi Thanh Tam
    Dang Thao Huong
    Nguyen Van Xang
    Nguyen Dong
    Le Thi Phuong
    Nguyen Van Hung
    Bui Duc Phu
    Tran My Phuc
    Thwaites, Guy E.
    Lu Lan Vi
    Rabaa, Maia A.
    Thompson, Corinne N.
    Baker, Stephen
    JOURNAL OF CLINICAL MICROBIOLOGY, 2016, 54 (04) : 1094 - 1100
  • [3] Evaluation of the Luminex xTAG Gastrointestinal Pathogen Panel and Analyte-Specific Reagents for the Detection of Enteropathogens in Stool
    Sefers, S.
    Chappell, J.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2013, 15 (06): : 886 - 886
  • [4] Added value of multiplex Luminex Gastrointestinal Pathogen Panel (xTAG® GPP) testing in the diagnosis of infectious gastroenteritis.
    Wessels, E.
    Rusman, L. G.
    van Bussel, M. J. A. W. M.
    Claas, E. C. J.
    CLINICAL MICROBIOLOGY AND INFECTION, 2014, 20 (03) : O182 - O187
  • [5] Evaluation of the Luminex xTAG Gastrointestinal Pathogen Panel and the Savyon Diagnostics Gastrointestinal Infection Panel for the detection of enteric pathogens in clinical samples
    Perry, Michael D.
    Garden, Sally A.
    Howe, Robin A.
    JOURNAL OF MEDICAL MICROBIOLOGY, 2014, 63 : 1419 - 1426
  • [6] Validation of Luminex xTAG Gastrointestinal Pathogen Panel with Stool Specimens in STAR Buffer
    Lee, S. D.
    Elshimali, Y.
    Lobos, J.
    Scarsella, A.
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2014, 16 (06): : 737 - 738
  • [7] Comparison of BioFire FilmArray gastrointestinal panel versus Luminex xTAG Gastrointestinal Pathogen Panel (xTAG GPP) for diarrheal pathogen detection in China
    Zhan, Zhifei
    Guo, Jiayin
    Xiao, Yong
    He, Zixiang
    Xia, Xin
    Huang, Zheng
    Guan, Hongxia
    Ling, Xia
    Li, Jie
    Diao, Baowei
    Zhao, Hongqun
    Kan, Biao
    Zhang, Jingyun
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2020, 99 : 414 - 420
  • [8] Comparative Evaluation of Seegene Allplex Gastrointestinal, Luminex xTAG Gastrointestinal Pathogen Panel, and BD MAX Enteric Assays for Detection of Gastrointestinal Pathogens in Clinical Stool Specimens
    Yoo, Jaeeun
    Park, Joonhong
    Lee, Hae Kyung
    Yu, Jin Kyung
    Lee, Gun Dong
    Park, Kang Gyun
    Oak, Ayeon Caitlyn
    Park, Yeon-loon
    ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2019, 143 (08) : 999 - 1005
  • [9] QIAstat-Dx gastrointestinal panel and Luminex xTAG gastrointestinal pathogen panel comparative evaluation
    Giffen, Samantha R.
    Sadler, Jacob M.
    Miller, Melissa B.
    JOURNAL OF CLINICAL MICROBIOLOGY, 2023, 61 (11)
  • [10] Application of the Luminex xTAG gastrointestinal pathogen panel for the detection of gastrointestinal pathogens in a rural African setting
    Eibach, D.
    Krumkamp, R.
    Hahn, A.
    Sarpong, N.
    Adu-Sarkodie, Y.
    Leva, A.
    Adlkofer, J.
    Panning, M.
    May, J.
    Tannich, E.
    TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2015, 20 : 117 - 117
123