Low modulus Ti-Nb-Hf alloy for biomedical applications

被引:36
|
作者
Gonzalez, M. [1 ,2 ]
Pena, J. [1 ,2 ]
Gil, F. J. [1 ,3 ]
Manero, J. M. [1 ,3 ]
机构
[1] Univ Politecn Cataluna, Dept Mat Sci & Met, E-08028 Barcelona, Spain
[2] Escola Super Disseny Engn Barcelona, Barcelona 08002, Spain
[3] Ciber BBN, Zaragoza, Spain
关键词
Corrosion; Biocompatibility; Cytotoxicity; Low elastic modulus; Stress shielding effect; TiNbHf alloys; CORROSION BEHAVIOR; TITANIUM;
D O I
10.1016/j.msec.2014.06.010
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
beta-Type titanium alloys with a low elastic modulus are a potential strategy to reduce stress shielding effect and to enhance bone remodeling in implants used to substitute failed hard tissue. For biomaterial application, investigation on the mechanical behavior, the corrosion resistance and the cell response is required. The new Ti25Nb16Hf alloy was studied before and after 95% cold rolling (95% C.R.). The mechanical properties were determined by tensile testing and its corrosion behavior was analyzed by potentiostatic equipment in Hank's solution at 37 degrees C. The cell response was studied by means of cytotoxicity evaluation, cell adhesion and proliferation measurements. The stress-strain curves showed the lowest elastic modulus (42 GPa) in the cold worked alloy and high tensile strength, similar to that of Ti6Al4V. The new alloy exhibited better corrosion resistance in terms of open circuit potential (E-OCP), but was similar in terms of corrosion current density (i(CORR)) compared to Ti grade II. Cytotoxicity studies revealed that the chemical composition of the alloy does not induce cytotoxic activity. Cell studies in the new alloy showed a lower adhesion and a higher proliferation compared toll grade II presenting, therefore, mechanical features similar to those of human cortical bone and, simultaneously, a good cell response. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:691 / 695
页数:5
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