Carboxyl-Assisted meta-Selective C-H Functionalizations of Benzylsulfonamides

被引：13
|
作者：
Cai, Lei [1 ,2 ]
Li, Shangda [1 ]
Zhou, Chunlin [1 ,2 ]
Li, Gang [1 ,2 ]
机构：
[1] Chinese Acad Sci, Ctr Excellence Mol Synth, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China
[2] Univ Chinese Acad Sci, Fujian Coll, Beijing 100049, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 20期
关键词：
TRACELESS DIRECTING GROUPS; BOND FORMATION; ACTIVATION; ARENES; ACIDS; ALKYLATION; ARYLATION; LIGAND; OLEFINATION; BORYLATION;
D O I：
10.1021/acs.orglett.0c02528
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A protocol of carboxyl-group-assisted, Pd(II)-catalyzed remote meta-C(sp(2))-H olefination and arylation of benzylsulfonamides has been developed. It was supposed to proceed through a kappa(2) coordination of the carboxyl group to the Pd center. These findings demonstrated the versatility of carboxyl-assisted remote meta-C-H activation strategy and might stimulate the exploration of novel reactivity and selectivity of other traditional chelating groups in different contexts.
引用
收藏
页码：7791 / 7796
页数：6
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