Micelle-Encapsulated Fluorescent Probe: Chemoselective and Enantioselective Recognition of Lysine in Aqueous Solution

被引：23
|
作者：
Du, Gengyu [1 ]
Pu, Lin [1 ]
机构：
[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 12期
基金：
美国国家科学基金会;
关键词：
AMINO-ACID OXIDASE; PEG-PLA; COPOLYMER; NANOPARTICLES;
D O I：
10.1021/acs.orglett.9b01661
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A diblock copolymer, poly(ethylene glycol) methyl ether-block-poly(L-lactide), is used to solubilize 3,3'-diformylBINOL (S)-1 in water to make the micelle-encapsulated fluorescent probe ML-S1. It was found that ML-S1 was able to recognize D-lysine chemoselectively as well as enantioselectively among 19 amino acids and their enantiomers in carbonate buffer. The enantioselective fluorescence enhancement ratio [ef = (I-D - I-0)/(I-D - I-0) = Delta I-D/Delta I-L] up to 6.6 was observed for the response of ML-S1+Zn(II) toward lysine.
引用
收藏
页码：4777 / 4781
页数：5
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