Teriflunomide in the treatment of multiple sclerosis: current evidence and future prospects

被引：31
|
作者：
Oh, Jiwon [1 ]
O'Connor, Paul W. [2 ]
机构：
[1] Univ Toronto, St Michaels Hosp, Dept Med, Div Neurol,MS Clin, Toronto, ON M5B 1W8, Canada
[2] Univ Toronto, St Michaels Hosp, Dept Med, Div Neurol, Toronto, ON M5B 1W8, Canada
来源：
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS | 2014年 / 7卷 / 05期
关键词：
clinical trials; multiple sclerosis; review; teriflunomide; DE-NOVO SYNTHESIS; RHEUMATOID-ARTHRITIS; ORAL TERIFLUNOMIDE; ACTIVE METABOLITE; HEALTHY HUMANS; T-LYMPHOCYTES; PHASE-3; TRIAL; A77; 1726; LEFLUNOMIDE; INHIBITION;
D O I：
10.1177/1756285614546855
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A number of novel oral agents are now approved for use in relapsing multiple sclerosis (MS). Among these agents, teriflunomide has shown promise with respect to clinical efficacy and safety in relapsing MS patients. In this review we aim to clarify the role of teriflunomide in the context of current and emerging MS treatment options by summarizing relevant points on the use of teriflunomide in MS, with a discussion of teriflunomide's pharmacologic properties, pivotal clinical trials, and safety and tolerability.
引用
收藏
页码：239 / 252
页数：14
相关论文
共 50 条
  • [1] The potential role for ocrelizumab in the treatment of multiple sclerosis: current evidence and future prospects
    Sorensen, Per Soelberg
    Blinkenberg, Morten
    [J]. THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS, 2016, 9 (01) : 44 - 52
  • [2] Treatment of secondary progressive multiple sclerosis - Current recommendations and future prospects
    Rice, GPA
    [J]. BIODRUGS, 1999, 12 (04) : 267 - 277
  • [3] Teriflunomide for the Treatment of Multiple Sclerosis
    Oh, Jiwon
    O'Connor, Paul W.
    [J]. SEMINARS IN NEUROLOGY, 2013, 33 (01) : 45 - 55
  • [4] Teriflunomide for treatment of multiple sclerosis
    Warnke, C.
    Hoerste, G. Meyer Zu
    Menge, T.
    Stueve, O.
    Hartung, H. -P.
    Wiendl, H.
    Kieseier, B. C.
    [J]. NERVENARZT, 2013, 84 (06): : 724 - 731
  • [5] Teriflunomide for the treatment of multiple sclerosis
    Warnke, Clemens
    Stueve, Olaf
    Kieseier, Bernd C.
    [J]. CLINICAL NEUROLOGY AND NEUROSURGERY, 2013, 115 : S90 - S94
  • [6] New evidence for teriflunomide in multiple sclerosis
    Kieseier, Bernd C.
    Wiendl, Heinz
    [J]. LANCET NEUROLOGY, 2014, 13 (03): : 234 - 235
  • [7] Immunoglobulin treatment of multiple sclerosis: future prospects
    L. Durelli
    A. Ricci
    E. Verdun
    [J]. Neurological Sciences, 2003, 24 : s234 - s238
  • [8] Immunoglobulin treatment of multiple sclerosis: future prospects
    Durelli, L
    Ricci, A
    Verdun, E
    [J]. NEUROLOGICAL SCIENCES, 2003, 24 (Suppl 4) : S234 - S238
  • [9] MRI in multiple sclerosis: current status and future prospects
    Bakshi, Rohit
    Thompson, Alan J.
    Rocca, Maria A.
    Pelletier, Daniel
    Dousset, Vincent
    Barkhof, Frederik
    Inglese, Matilde
    Guttmann, Charles R. G.
    Horsfield, Mark A.
    Filippi, Massimo
    [J]. LANCET NEUROLOGY, 2008, 7 (07): : 615 - 625
  • [10] Teriflunomide (Aubagio®) for the treatment of multiple sclerosis
    Bar-Or, Amit
    [J]. EXPERIMENTAL NEUROLOGY, 2014, 262 : 57 - 65
12345