Serum brain-derived neurotrophic factor (BDNF) is not regulated by testosterone in transmen

被引：6

作者：

Auer, Matthias K. ^{[1
]}

Hellweg, Rainer ^{[2
]}

Briken, Peer ^{[3
]}

Stalla, Guenter K. ^{[1
]}

T'Sjoen, Guy ^{[4
]}

Fuss, Johannes ^{[3
]}

机构：

[1] Max Planck Inst Psychiat, Endocrinol Diabetol & Internal Med, D-80804 Munich, Germany

[2] Univ Med Berlin, Dept Psychiat, Campus Charite Mitte, D-10117 Berlin, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Ctr Psychosocial Med, Inst Sex Res & Forens Psychiat, D-20246 Hamburg, Germany

[4] Ghent Univ Hosp, Dept Endocrinol, B-9000 Ghent, Belgium

来源：

BIOLOGY OF SEX DIFFERENCES | 2016年 / 7卷

关键词：

Transsexualism; Estradiol; Sex steroids; Testosterone; Brain-derived neurotropic factor; BDNF; Gender dysphoria; Brain morphology; Platelets; SEX HORMONE-TREATMENT; HUMAN PLATELETS; GENDER; PLASMA; ANDROGEN; RELEASE; TRANSSEXUALISM; PROGESTERONE; RECEPTOR; THERAPY;

D O I：

10.1186/s13293-015-0055-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Brain morphology significantly differs between the sexes. It has been shown before that some of these differences are attributable to the sex-specific hormonal milieu. Brain-derived neurotrophic factor (BDNF) is involved in myriads of neuroplastic processes and shows a sexual dimorphism. Transsexual persons may serve as a model to study sex steroid-mediated effects on brain plasticity. We have recently demonstrated that serum levels of BDNF are reduced in transwomen following 12 months of cross-sex hormone treatment. We now wanted to look at the effects of testosterone treatment on BDNF in transmen. In contrast to our initial hypothesis, BDNF levels did not significantly change, despite dramatic changes in the sex-hormonal milieu. Our data indicate that testosterone does not seem to play a major role in the regulation of BDNF in females.

引用

页数：6

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