Synthesis of spiro[isoquinolinone-4,2′-oxiranes] and isoindolinones via a multicomponent reaction of 2-acetyl-oxirane-2-carboxamides, arylaldehydes and malononitrile

被引：9
|
作者：
Liu, Bing [1 ]
Wei, Enxiang [1 ]
Lin, Shaoxia [1 ]
Zhao, Baozhong [1 ]
Liang, Fushun [1 ,2 ]
机构：
[1] NE Normal Univ, Dept Chem, Changchun 130024, Peoples R China
[2] NE Normal Univ, Minist Educ, Key Lab UV Emitting Mat & Technol, Changchun 130024, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 53期
关键词：
ONE-STEP SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; 3-COMPONENT REACTION; HIGHLY EFFICIENT; HYDROGEN-BOND; CYCLOADDITION; DERIVATIVES; CYCLIZATION; ALDEHYDES; EPOXIDATION;
D O I：
10.1039/c4cc02141j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Efficient synthesis of spiro[isoquinolinone-4,2'-oxiranes] was achieved based on a multicomponent one-pot reaction of readily available cis-2-acetyl-oxirane-2-carboxamides, arylaldehydes and malononitrile at room temperature. However, in the reaction with trans-2-acetyl-oxirane-2-carboxamide substrates, 3-iminoisoindolinones were obtained in moderate to high yields.
引用
收藏
页码：6995 / 6997
页数：3
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