The Genetic Complexity of Prostate Cancer

被引：9

作者：

Comperat, Eva ^{[1
,2
,3
]}

Wasinger, Gabriel ^{[3
]}

Oszwald, Andre ^{[3
]}

Kain, Renate ^{[3
]}

Cancel-Tassin, Geraldine ^{[1
]}

Cussenot, Olivier ^{[1
,4
]}

机构：

[1] Sorbonne Univ, CeRePP, GRC5 Predict Onco Urol, F-75020 Paris, France

[2] Sorbonne Univ, Dept Pathol, Hop Tenon, F-75020 Paris, France

[3] Med Univ Vienna, Dept Pathol, A-1090 Vienna, Austria

[4] Sorbonne Univ, Dept Urol, Hop Tenon, F-75020 Paris, France

来源：

GENES | 2020年 / 11卷 / 12期

关键词：

prostate cancer; germline mutations; somatic mutations; PTEN; TMPRSS2; ERG; androgen receptors; ANDROGEN RECEPTOR; CONSENSUS CONFERENCE; DNA-REPAIR; MUTATIONS; SPOP; RISK; EXPRESSION; GERMLINE; SURVIVAL; FUSION;

D O I：

10.3390/genes11121396

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Prostate cancer (PCa) is a major concern in public health, with many genetically distinct subsets. Genomic alterations in PCa are extraordinarily complex, and both germline and somatic mutations are of great importance in the development of this tumor. The aim of this review is to provide an overview of genetic changes that can occur in the development of PCa and their role in potential therapeutic approaches. Various pathways and mechanisms proposed to play major roles in PCa are described in detail to provide an overview of current knowledge.

引用

页码：1 / 12

页数：12

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