Self-assembly of biomolecular soft matter

被引:77
|
作者
Stupp, Samuel I. [1 ,2 ,3 ,4 ]
Zha, R. Helen [1 ]
Palmer, Liam C. [2 ]
Cui, Honggang [1 ]
Bitton, Ronit [4 ]
机构
[1] Northwestern Univ, Dept Mat Sci & Engn, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA
[3] Northwestern Univ, Dept Med, Chicago, IL 60611 USA
[4] Northwestern Univ, Inst BioNanotechnol Med, Chicago, IL 60611 USA
基金
美国国家卫生研究院;
关键词
PEPTIDE-AMPHIPHILE NANOFIBERS; SUPRAMOLECULAR NANOFIBERS; ANTITUMOR-ACTIVITY; BONE REGENERATION; NANOSTRUCTURES; MOLECULES; DNA; MINERALIZATION; MATRICES; POLYMERS;
D O I
10.1039/c3fd00120b
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Self-assembly programmed by molecular structure and guided dynamically by energy dissipation is a ubiquitous phenomenon in biological systems that build functional structures from the nanoscale to macroscopic dimensions. This paper describes examples of one-dimensional self-assembly of peptide amphiphiles and the consequent biological functions that emerge in these systems. We also discuss here hierarchical self-assembly of supramolecular peptide nanostructures and polysaccharides, and some new results are reported on supramolecular crystals formed by highly charged peptide amphiphiles. Reflecting on presentations at this Faraday Discussion, the paper ends with a discussion of some of the future opportunities and challenges of the field.
引用
收藏
页码:9 / 30
页数:22
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