DNA methylation changes in leukaemia

被引：58
|
作者：
Melki, JR
Clark, SJ
机构：
[1] Royal Prince Alfred Hosp, Sydney Canc Ctr, Kanematsu Labs, Camperdown, NSW 2050, Australia
[2] Univ Sydney, Fac Med, Sydney, NSW 2050, Australia
[3] CSIRO, Sydney Lab, Mol Sci, N Ryde, NSW 1670, Australia
来源：
SEMINARS IN CANCER BIOLOGY | 2002年 / 12卷 / 05期
关键词：
cancer; epigenetic; leukaemia; methylation; DNA methyltransferase;
D O I：
10.1016/S1044-579X(02)00055-X
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Leukaemogenesis is a multi-step Process whereby a clonal population misers that has undergone successive alterations to the genotype and the phenotype of the cells that make up the clone. Leukaemia has traditionally been viewed as a genetic disease, however epigenetic defects also play an important role. Expression of the DNA methyltransferase enzymes is elevated in leukaemia, and aberrant methylation is common with both a decrease in the total genomic 5-methylcytosine, and a concomitant hypermethylation of CpG island-associated tumour suppressor genes. This review will discuss the multitude of DNA methylation changes in haematopoietic malignancies and the implications they have for diagnosis and treatment.
引用
收藏
页码：347 / 357
页数：11
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