Current Progress on MicroRNA-Based Gene Delivery in the Treatment of Osteoporosis and Osteoporotic Fracture

被引：39
|
作者：
Sun, Xi [1 ,2 ]
Guo, Qi [2 ]
Wei, Wenhua [3 ]
Robertson, Stephen [3 ]
Yuan, Ying [2 ]
Luo, Xianghang [2 ]
机构：
[1] Cent South Univ, Xiangya Hosp 3, Dept Endocrinol, 138 Tongzipo Rd, Changsha 410007, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Endocrinol, Endocrinol Res Ctr, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
[3] Univ Otago, Dunedin Sch Med, Dept Womens & Childrens Hlth, Dunedin 9016, New Zealand
来源：
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2019年 / 2019卷
基金：
中国国家自然科学基金;
关键词：
MESENCHYMAL STEM-CELLS; DIFFERENTIATION IN-VITRO; ENHANCES BONE-FORMATION; EXTRACELLULAR VESICLES; REGULATES OSTEOCLASTOGENESIS; OSTEOGENIC DIFFERENTIATION; LIPID NANOPARTICLES; POSITIVE REGULATION; GOLD NANOPARTICLES; PROTEIN EXPRESSION;
D O I：
10.1155/2019/6782653
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Emerging evidence demonstrates that microRNAs, as important endogenous posttranscriptional regulators, are essential for bone remodeling and regeneration. Undoubtedly, microRNA-based gene therapies show great potential to become novel approaches against bone-related diseases, including osteoporosis and associated fractures. The major obstacles for continued advancement of microRNA-based therapies in clinical application include their poor in vivo stability, nonspecific biodistribution, and unwanted side effects. Appropriate chemical modifications and delivery vectors, which improve the biological performance and potency of microRNA-based drugs, hold the key to translating miRNA technologies into clinical practice. Thus, this review summarizes the current attempts and existing deficiencies of chemical modifications and delivery systems applied in microRNA-based therapies for osteoporosis and osteoporotic fractures to inform further explorations.
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收藏
页数：17
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