Involvement of Rac/Cdc42/PAK pathway in cytoskeletal rearrangements

被引：1
|
作者：
Szczepanowska, Joanna [1 ]
机构：
[1] Polish Acad Sci, Nencki Inst Expt Biol, Lab Bioenerget & Biomembranes, PL-02093 Warsaw, Poland
来源：
ACTA BIOCHIMICA POLONICA | 2009年 / 56卷 / 02期
关键词：
PAK kinase; Rho GTPases; cytoskeletal organization; PAK substrates; REGULATORY LIGHT-CHAIN; P21-ACTIVATED KINASE-1-INTERACTING SUBSTRATE; ACANTHAMOEBA MYOSIN I; NF2; TUMOR-SUPPRESSOR; RHO EXCHANGE FACTOR; PROTEIN-KINASE; PHOSPHORYLATION SITES; SPINE MORPHOGENESIS; HUMAN CANCER; LIM-KINASE;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The p21-activated kinases (PAKs) are serine/threonine protein kinases interacting with small GTPases - Rac and Cdc42. PAKs are found in most eukaryotes and play an evolutionarily conserved role in many cellular processes. Six human PAKs have been identified, and based on homology, they can be classified into two groups. This review focuses specifically on the role of Rac/Cdc42 regulated PAKs in maintaining and remodeling cytoskeletal structure in various organisms. A list of PAKs substrates and binding partners implicated directly and indirectly in cytoskeletal reorganization is presented. Also perturbations of the Rac/Cdc42/PAK pathway leading to tumorigenesis and neurodegenerative diseases are reviewed.
引用
收藏
页码：225 / 234
页数：10
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