Successful treatment of severe psoriasis and psoriatic arthritis with adalimumab

被引：44
|
作者：
Chew, AL
Bennett, A
Smith, CH
Barker, J [1 ]
Kirkham, B
机构：
[1] St Thomas Hosp, Guys Kings & St Thomas Sch Med, St Johns Inst Dermatol, Skin Therapy Res Unit, London SE1 7EH, England
[2] Guys & St Thomas Hosp, Dept Rheumatol, London SE1 9RT, England
来源：
BRITISH JOURNAL OF DERMATOLOGY | 2004年 / 151卷 / 02期
关键词：
adalimumab; antitumour necrosis factor-alpha monoclonal antibody; D2E7; Humira((R)); psoriasis; psoriatic arthritis;
D O I：
10.1111/j.1365-2133.2004.06105.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Adalimumab, a fully human-derived recombinant monoclonal antibody against tumour necrosis factor-alpha, has been shown to be effective for the treatment of patients with moderately to severely active rheumatoid arthritis. We report two patients with long-standing recalcitrant psoriasis and psoriatic arthritis who, after multiple treatment failures with conventional and experimental antipsoriatic medications, both responded to treatment with adalimumab. Significant clinical improvement was noted in both skin and joint disease in the two patients after several weeks of treatment with adalimumab. We are unaware of previous published reports of adalimumab therapy in patients with psoriasis and psoriatic arthritis.
引用
收藏
页码：492 / 496
页数：5
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