miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer

被引：70
|
作者：
Tan, Hong [1 ,2 ]
He, Qingnan [3 ]
Gong, Guanhui [2 ]
Wang, Yixuan [1 ,2 ]
Li, Juanni [1 ,2 ]
Wang, Junpu [1 ,2 ]
Zhu, Ding [1 ,2 ]
Wu, Xiaoying [1 ,2 ]
机构：
[1] Cent S Univ, Dept Pathol, Sch Basic Med Sci, Changsha 410013, Hunan, Peoples R China
[2] Cent S Univ, Dept Pathol, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China
[3] Cent S Univ, Childrens Med Ctr, Xiangya Hosp 2, Changsha 410011, Hunan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 2016年 / 48卷 / 01期
基金：
中国国家自然科学基金;
关键词：
miR-382; ovarian cancer; receptor tyrosine kinase orphan receptor 1; epithelial-mesenchymal transition; migration; invasion; EPITHELIAL-MESENCHYMAL TRANSITION; MICRORNAS; DIAGNOSIS; PROGNOSIS; METASTASIS; CARCINOMA; MIRNAS;
D O I：
10.3892/ijo.2015.3241
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR-382 has been observed in various types of cancers. However, the biological function of miRNA-382 in ovarian cancer is still largely unknown. Here, we found miR-382 was downregulated in human ovarian cancer tissues and cell lines. miR-382 inhibited ovarian cancer cell proliferation, migration, invasion and the epithelial-mesenchymal transition (EMT). Furthermore, we identified receptor tyrosine kinase orphan receptor 1 (ROR1) as a target of miR-382, and miR-382 rescued the promotion effect of ROR1 on migration, invasion and EMT process in SKOV3 and COV434 cells. Collectively, these findings revealed that miR-382 inhibits migration and invision by targeting ROR1 through regulating EMT in ovarian cancer, and might serve as a tumor suppressor in ovarian cancer.
引用
收藏
页码：181 / 190
页数：10
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