Incidence and evolution of sepsis-induced cardiomyopathy in a cohort of patients with sepsis and septic shock

Objetive: The aim of this study was to establish the incidence of septic cardiomyopathy (SM) in patients with sepsis and septic shock, to describe its characteristics and testing its evolution. Design: Prospective cohort study. Participants: We included 57 consecutive patients admitted to Intensive Care Unit, who met criteria of sepsis and septic shock. Principal variables of interest: Clinical and biochemical variables were analyzed. An echocar-diogram was performed in the first 24 hours of admission, determining myocardial function parameters, and if the patients had left ventricular ejection fraction (LVEF} < 50%) a second echocardiogram was performed. Ambit: Intensive medical and surgical Care Service for Adults in University Hospital. Results: The mean age of the patients was 62,1 +/- 16,3 years. 58% were males. 22.8% had left ventricular dysfunction. The mean LVEF in patients with MS was lower than those without SM (34.1 +/- 10.6 vs 60.7 +/- 6.94%, P < .001), with complete recovery, in survivors, after the acute event (LVEF at discharge 56.1 +/- 6.3% P = .04). Patients with SM had higher levels of procalcitonin (47.1 +/- 35.4 vs 18.9 +/- 24.5; P = .02) and higher score on the Sequential Organ Failure Assessment (SOFA score) (9.91 +/- 3.82 vs 7.47 +/- 3.41; P = .037). Mortality was not significantly different between both groups [4 (30.8%) vs 4 (9.1%); P = .07]. Conclusions: SM is not uncommon and is related to a higher scores on the severity scales. In the survivors, LVEF normalized after the recovery of the acute event. (C) 2017 Elsevier Espana, S.L.U. y SEMICYUC. All rights reserved.