Targets of drug action

被引：5
|
作者：
Burgen, ASV [1 ]
机构：
[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1QJ, England
来源：
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY | 2000年 / 40卷
关键词：
acetylcholine; botulinum; carbonic anhydrase; conformation; DHFR; drug design; muscarinic; NMR; receptors;
D O I：
10.1146/annurev.pharmtox.40.1.1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This article considers early work from the author's laboratory on muscarinic receptor specificity, subtypes, and conformational variability, with the use of nuclear magnetic resonance in pharmacology and the conformational variants of dihydrofolate reductase and general questions of receptors. It also considers some current approaches to drug development and receptor function, particularly as influenced by increasing knowledge of three-dimensional structure of receptors.
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页码：1 / 16
页数：16
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