Signal transductions and nonalcoholic fatty liver: a mini-review

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease, and the incidence increases year by year. The pathogenesis of NAFLD is correlated with insulin resistant (IR), and oxidative stress which induces varied inflammatory cytokines (TNF-alpha, IL-1, IL-6, etc). Different signal transductions such as MAPK, NF-kappa B, AMPK, JAK2/STAT3, PPAR, PI3K/Akt, TLR were activated by the pathogenic factors to regulate correlative reactions. Thus, indepth study of the signal transductions will probably provide new suitable solutions for the prevention and therapy of NAFLD.