Transplacental-transfer of naltrexone in rats

被引：12
|
作者：
Zagon, IS [1 ]
Hurst, WJ [1 ]
McLaughlin, PJ [1 ]
机构：
[1] PENN STATE UNIV,COLL MED,DEPT COMPARAT MED,HERSHEY,PA 17033
来源：
LIFE SCIENCES | 1997年 / 61卷 / 13期
关键词：
naltrexone; opioid antagonist; transplacental; opioid growth factor; Met(5)]-enkephalin; reversed phase HPLC; heart; brain;
D O I：
10.1016/S0024-3205(97)00671-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Extracts of fetal (20 days gestation) brain, heart, end liver were evaluated for naltrexone in rats 1 hour following maternal injection of 50 mg/kg opioid antagonist; adult plasma from the pregnant rats was analyzed. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed phase high-performance liquid chromatography with ultraviolet detection. This qualitative analysis revealed the presence of naltrexone in all fetal tissues, as well as in adult plasma. These results indicate naltrexone, maternally administered, passes through the placenta and enters the fetus. The data would suggest that reports concerning somatic and neurobiological acceleration in offspring exposed to naltrexone during gestation, may be the result of a direct opioid antagonist action in the fetus.
引用
收藏
页码：1261 / 1267
页数：7
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