Too much of a good thing: Management of BCG vaccine overdose

被引：12

作者：

Ritz, Nicole ^{[1
,2
,3
]}

Tebruegge, Marc ^{[1
,2
,3
]}

Streeton, Jonathan ^{[4
]}

Curtis, Nigel ^{[1
,2
,3
]}

机构：

[1] Univ Melbourne, Dept Paediat, Parkville, Vic 3052, Australia

[2] Royal Childrens Hosp Melbourne, Dept Gen Med, Infect Dis Unit, Melbourne, Vic, Australia

[3] Murdoch Childrens Res Inst, Melbourne, Vic, Australia

[4] St Vincents & Mercy Private Hosp, Melbourne, Australia

来源：

VACCINE | 2009年 / 27卷 / 41期

关键词：

BCG; Overdose; Vaccine; Immunisation; Tuberculosis; Medical error; BACILLE CALMETTE-GUERIN; LYMPHADENITIS; TUBERCULOSIS;

D O I：

10.1016/j.vaccine.2009.07.043

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 14-year-old girl was inadvertently immunised with an excessively large dose of BCG-Connaught vaccine (1.0 ml instead of 0.1 ml). Examination of the patient a few hours later revealed a subcutaneous fluctuant tender lump at the injection site. This was surgically excised within 12 h of immunisation and she was treated with isoniazid and rifampicin for six weeks. The patient developed no complications, other than a minor surgical scar. This case highlights the importance of the correct administration and dosing of BCG vaccine and suggests a management option that may prevent the severe local and systemic complications that are frequently associated with BCG overdose. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5562 / 5564

页数：3

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