Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gallbladder, and Extrahepatic Biliary Tract 2018 Update

被引：5
|
作者：
Zhang, Lei [1 ]
Bluth, Martin H. [2 ,3 ]
Bhalla, Amarpreet [4 ]
机构：
[1] Univ Buffalo, Buffalo Gen Hosp, Jacobs Sch Med & Biomed Sci, Dept Pathol & Anat Sci, 100 High St, Buffalo, NY 14203 USA
[2] Wayne State Univ, Dept Pathol, Sch Med, 540 East Canfield St, Detroit, MI 48201 USA
[3] Michigan Surg Hosp, Pathol Labs, 21230 Dequindre Rd, Warren, MI 48091 USA
[4] Univ Buffalo SUNY, Dept Pathol & Anat Sci, Jacobs Sch Med & Biomed Sci, Buffalo Gen Hosp A-701,100 High St, Buffalo, NY 14203 USA
来源：
CLINICS IN LABORATORY MEDICINE | 2018年 / 38卷 / 02期
关键词：
Pancreatic neoplasms; Liver; Hepatic adenoma; Hepatocellular carcinoma; Cholangiocarcinoma; Molecular diagnostics; Cell free nucleic acid; ACINAR-CELL-CARCINOMA; SPORADIC NEUROENDOCRINE TUMORS; PAPILLARY MUCINOUS NEOPLASMS; DNA-REPAIR GENES; K-RAS; BETA-CATENIN; HEPATOCELLULAR ADENOMA; MALIGNANT-TRANSFORMATION; P53; OVEREXPRESSION; CYSTIC NEOPLASMS;
D O I：
10.1016/j.cll.2018.03.003
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Pancreatic neoplasms, including ductal adenocarcinoma, solid pseudopapillary neoplasm, pancreatic endocrine neoplasms, acinar cell carcinoma, and pancreatoblastoma, are associated with different genetic abnormalities. Hepatic adenomas with beta-catenin exon 3 mutation are associated with a high risk of malignancy. Hepatic adenoma with arginosuccinate synthetase 1 expression or sonic hedgehog mutations are associated with a risk of bleeding. Hepatocellular carcinoma and cholangiocarcinoma display heterogeneity at both morphologic and molecular levels. Cholangiocellular carcinoma is most commonly associated with IDH 1/2 mutations.
引用
收藏
页码：367 / +
页数：19
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