Belgian recommendations on ANA, anti-dsDNA and anti-ENA antibody testing

被引：14

作者：

Van Blerk, M. ^{[1
,2
]}

Bossuyt, X. ^{[2
,3
]}

Humbel, R. ^{[2
,4
]}

Mewis, A. ^{[2
,5
]}

Servais, G. ^{[2
,6
]}

Tomasi, J. P. ^{[2
,7
]}

Van Campenhout, C. ^{[1
,2
]}

Van Hoovels, L. ^{[2
,8
]}

Vercammen, M. ^{[2
,9
]}

Damoiseaux, J. ^{[10
]}

Coucke, W. ^{[1
]}

Van de Walle, P. ^{[1
]}

机构：

[1] Sci Inst Publ Hlth, Dept Qual Med Labs, Brussels, Belgium

[2] EQA Advisory Board, Brussels, Belgium

[3] Katholieke Univ Leuven, Univ Ziekenhuizen Leuven, Lab Geneeskunde, Louvain, Belgium

[4] Lab Luxembourgeois Immunopathol, Esch Sur Alzette, Luxembourg

[5] Jessa Ziekenhuis, Klin Lab, Hasselt, Belgium

[6] Ctr Hosp Univ Brugmann, Lab Immunol, Brussels, Belgium

[7] Clin Univ St Luc, Lab Autoimmunite, B-1200 Brussels, Belgium

[8] Onze Lieve Vrouw Hosp, Klin Lab, Aalst, Belgium

[9] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Lab Hematol, Brussels, Belgium

[10] Maastricht Univ, Med Ctr, Cent Diagnost Lab, Maastricht, Netherlands

来源：

ACTA CLINICA BELGICA | 2014年 / 69卷 / 02期

关键词：

Antinuclear antibodies; Anti-dsDNA antibodies; Anti-ENA antibodies; Recommendations; External quality assessment; GUIDELINES; AUTOANTIBODIES;

D O I：

10.1179/2295333714Y.0000000010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Autoantibodies to nuclear antigens, i.e. antinuclear antibodies (ANA), antibodies to double-stranded DNA (dsDNA) and extractable nuclear antigens (ENA), are useful as diagnostic markers for a variety of autoimmune diseases. In March 2010, the Belgian national External Quality Assessment Scheme sent a questionnaire on ANA, anti-dsDNA and anti-ENA antibody testing designed by the Dutch EASI (European Autoimmunity Standardization Initiative) team, to all clinical laboratories performing ANA testing. Virtually all laboratories completed the questionnaire (97.7%, 127/130). This paper discusses the results of this questionnaire and provides valuable information on the state-of-the-art of ANA, anti-dsDNA and anti-ENA antibody testing as practiced in the Belgian laboratories. In addition, this work presents practical recommendations developed by the members of the advisory board of the scheme as a result of the outcome of this study.

引用

页码：83 / 86

页数：4

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