Platinum drugs binding to human serum albumin: Effect of non-steroidal anti-inflammatory drugs

被引：27

作者：

Wiglusz, Katarzyna ^{[1
]}

Trynda-Lemiesz, Lilianna ^{[1
]}

机构：

[1] Wroclaw Med Univ, Fac Pharm, Dept Analyt Chem, PL-50566 Wroclaw, Poland

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY | 2014年 / 289卷

关键词：

Human serum albumin; Platinum complexes; NSAIDs; Fluorescence; Circular dichroism; PROTEIN-BINDING; CISPLATIN; MELOXICAM; WARFARIN; OXALIPLATIN; ASPIRIN; PHARMACOKINETICS; SPECTROMETRY; COMBINATION; INHIBITION;

D O I：

10.1016/j.jphotochem.2014.05.013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this report, we provide investigations about the effect of Sudlow's site I and II blockers on the platinum anticancer drugs binding. The effect of warfarin, aspirin, ibuprofen and meloxicam on the platinum binding to HSA has been investigated through gel-filtration chromatography, UV-vis, CD, fluorescence spectroscopy and the inductively coupled plasma atomic emission spectroscopy (ICP(AES)) method. The results confirm that the platinum complexes bind to Sudlow's site I and II. Modifications of the protein structure caused by non-steroidal anti-inflammatory drugs (NSAIDs) that bind in these areas have an impact on the amount of cisplatin bound to albumin. The number of bound cisplatin was reduced by approximately 30-40% compared to the native protein. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：1 / 6

页数：6

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[J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 1966, 94 (07) : 358 - +
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