Synthesis, spectroscopic characterization, and biological applications of organotin(IV) derivatives of 2-(N-maleoyl)-3-phenylpropanoic acid

In an effort to develop new organotin materials for investigation and biocidal evaluation, a series of compounds with the general formula R4-nSnLn (where R = CH3, n-C4H9, C6H5, C6H5CH2 and L = 2-(N-maleoyl)-3-phenylpropanoic acid anion) have been synthesized, and characterized by elemental analyses, IR, multinuclear (H-1, C-13 and Sn-119) NMR and mass spectrometry. The biological activity of these compounds against various bacteria and fungi has been investigated. All of the compounds were found to be active against the tested fungi with a few exceptions. These compounds also showed significant antibacterial activity. LD50 data show that the investigated compounds also have significant toxicity.