Potential impact of SARS-CoV-2 infection on the thymus

被引:15
|
作者
Lins, Marvin Paulo [1 ,2 ]
Smaniotto, Salete [1 ,2 ]
机构
[1] Univ Fed Alagoas, Inst Biol & Hlth Sci, Lab Cell Biol, Maceio, Alagoas, Brazil
[2] Brazilian Natl Inst Sci & Technol Neuroimmunomodu, Rio De Janeiro, Brazil
关键词
thymus; coronavirus; lymphopenia; MOUSE HEPATITIS-VIRUS; SARS-CORONAVIRUS; CELLS; DIFFERENTIATION; MACROPHAGES; MECHANISMS; EXPRESSION; TOLERANCE; DISEASE; LIMITS;
D O I
10.1139/cjm-2020-0170
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Understanding the pathogenesis of certain viral agents is essential for developing new treatments and obtaining a clinical cure. With the onset of the new coronavirus (SARS-CoV-2) pandemic in the beginning of 2020, a rush to conduct studies and develop drugs has led to the publication of articles that seek to address knowledge gaps and contribute to the global scientific research community. There are still no reports on the infectivity or repercussions of SARS-CoV-2 infection on the central lymphoid organ, the thymus, nor on thymocytes or thymic epithelial cells. In this brief review, we present a hypothesis about lymphopenia observed in SARS patients and the probable pathological changes that the thymus may undergo due to this new virus.
引用
收藏
页码:23 / 28
页数:6
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