Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling

被引：0
|
作者：
Brisken, C
Heineman, A
Chavarria, T
Elenbaas, B
Tan, J
Dey, SK
McMahon, JA
McMahon, AP
Weinberg, RA [1 ]
机构：
[1] Whitehead Inst, Dept Mol & Integrat Physiol, Cambridge, MA 02142 USA
[2] Univ Kansas, Med Ctr, Kansas City, KS 66160 USA
[3] Harvard Univ, Biol Labs, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
来源：
GENES & DEVELOPMENT | 2000年 / 14卷 / 06期
关键词：
mammary gland; morphogenesis; Wnt-4; signaling; side-branching; progesterone function;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Female reproductive hormones control mammary gland morphogenesis,In the absence of the progesterone receptor (PR) from the mammary epithelium, ductal side-branching fails to occur. We can overcome this defect by ectopic expression of the protooncogene Wnt-1. Transplantation of mammary epithelia from Wnt-4(-)/(-) mice shows that Wnt-4 has an essential role in side-branching early in pregnancy. PR and Wnt-4 mRNAs colocalize to the luminal compartment of the ductal epithelium. Progesterone induces Wnt-4 in mammary epithelial cells and is required for increased Wnt-4 expression during pregnancy. Thus, Wnt signaling is essential in mediating progesterone function during mammary gland morphogenesis.
引用
收藏
页码：650 / 654
页数：5
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