A pseudo-quadruple hydrogen-bonding motif consisting of six N-H•••O hydrogen bonds in trimethoprim formate

被引：22
|
作者：
Umadevi, B [1 ]
Prabakaran, P [1 ]
Muthiah, PT [1 ]
机构：
[1] Bharathidasan Univ, Dept Chem, Tiruchirappalli 620024, India
来源：
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY | 2002年 / 58卷
关键词：
D O I：
10.1107/S0108270102011150
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The title compound, trimethoprim (TMP) formate [systematic name: 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidin-1-ium formate], C14H19N4O3+.CHO2-, reveals a pseudo-quadruple hydrogen-bonding motif consisting of six N-H...O hydrogen bonds involving two unpaired TMP cations and two formate anions which are symmetrically disposed. The hydrogen-bonding motif is strikingly comparable with that observed in other TMP salts where the aminopyrimidine moieties of the TMP cations are centrosymmetrically paired. These conserved hydrogen-bonding motifs may serve as robust synthons in crystal engineering and design. The characteristic pseudoquadruple hydrogen-bonding motif and other intermolecular hydrogen bonds operating in the crystal form a two-dimensional supramolecular sheet structure.
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收藏
页码：o510 / o512
页数：3
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