No Increase in HIV Drug Resistance Mutations among Injecting Drug Users on Methadone Maintenance Therapy: A Prospective Cohort Study

被引:0
|
作者
Huang, Chunyuan [1 ]
Ye, Li [1 ]
Abdullah, Abu S. [3 ]
Liang, Bingyu [1 ]
Jiang, Junjun [1 ]
Ning, Chuanyi [1 ,2 ]
Zang, Ning [1 ,2 ]
Zhang, Yu [1 ]
Yang, Yuan [1 ]
Hu, Xi [1 ]
Yang, Quanlue [1 ]
Luo, Chaolian [1 ,2 ]
Lao, Feixiang [1 ]
Liu, Huifang [1 ,2 ]
Liang, Hao [1 ,2 ]
Huang, Jiegang [1 ]
机构
[1] Guangxi Med Univ, Sch Publ Hlth, Guangxi Univ Key Lab Prevent & Control Highly Pre, Guangxi Key Lab AIDS Prevent & Treatment, Nanning 530021, Guangxi, Peoples R China
[2] Guangxi Med Univ, Life Sci Inst, Gnangxi Collaborat Innovat Ctr Biomed, Nanning 530021, Guangxi, Peoples R China
[3] Boston Univ, Sch Med, Dept Med, Boston Med Ctr, Boston, MA 02118 USA
基金
中国国家自然科学基金;
关键词
HIV-positive; methadone maintenance therapy; injecting drug users; antiretroviral-treatment; drug resistance mutations; cohort study; TREATMENT-NAIVE PATIENTS; ANTIRETROVIRAL THERAPY; TREATMENT OUTCOMES; TYPE-1; INFECTION; POSITIVE PEOPLE; RISK BEHAVIORS; PROVIRAL DNA; TRANSMISSION; ADHERENCE; REDUCTION;
D O I
10.2174/1570162X18666200712173630
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. Objective: To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (ART) HIV-positive IDUs and non-drug users. Methods: A prospective cohort of ART HIV-positive patients including IDUs who received MMT (MMT group) and non-drug users (N-MMT group) was established from April 2016 to December 2017 in Guangxi, China. Results: Of the 80 participants, 43 were in the MMT group and 37 were in the N-MMT group. Compared with the N-MMT group, the HRs of PIs, NRTIs and NNRTIs for new DRMs in the MMT group was 1.55 (95%CI: 0.28-8.64; P = 0.616), 1.51 (95%CI: 0.44-5.20; P = 0.512) and 0.45 (95%CI: 0.15-1.35; P = 0.155), respectively. There was no dose-response relationship between MMT and new DRMs for PIs, NRTIs and NNRTIs (P > 0.05). The new DRM incidence for NRTIs (138.23 per 10(4) person-months) was higher than for PIs (94.16 per 10(4) person-months) and NNRTIs (95.41per 10(4) person-months) in the MMT group, while the new DRM incidence for NNRTIs (208.24 per 10(4) person-months) was higher than for PIs (44.13 per 10(4) person-months) and NRTIs (91.78 per 10(4) person-months) in the N-MMT group. Conclusion: Among ART HIV-positive patients, there is no significant difference in the incidence of new DRMs between IDUs receiving MMT and non-drug users. MMT has little impact on the development of DRMs among IDUs.
引用
收藏
页码:362 / 372
页数:11
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