Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI )

被引：41

作者：

Canonica, Giorgio Walter ^{[1
,2
]}

Blasi, Francesco ^{[3
,4
,5
]}

Paggiaro, Pierluigi ^{[6
]}

Senna, Gianenrico ^{[7
]}

Passalacqua, Giovanni ^{[8
]}

Spanevello, Antonio ^{[9
]}

Aliberti, Stefano ^{[3
,4
,5
]}

Bagnasco, Diego ^{[8
]}

Bonavia, Marco ^{[10
]}

Bonini, Matteo ^{[11
]}

Brussino, Luisa ^{[12
,13
,14
]}

Bucca, Caterina ^{[12
,13
,14
]}

Caiaffa, Maria F. ^{[15
]}

Calabrese, Cecilia ^{[16
]}

Camiciottoli, Gianna ^{[17
]}

Caminati, Marco ^{[7
]}

Carpagnano, Giovanna E. ^{[18
]}

Caruso, Cristiano ^{[19
]}

Centanni, Stefano ^{[20
]}

Conte, Maria E. ^{[21
]}

Corsico, Angelo G. ^{[22
]}

Cosmi, Lorenzo ^{[23
]}

Costantino, Maria T. ^{[24
]}

Crimi, Nunzio ^{[25
]}

D'Alo, Simona ^{[26
]}

D'Amato, Maria ^{[27
]}

Del Giacco, Stefano ^{[28
]}

Farsi, Alessandro ^{[29
]}

Favero, Elisabetta ^{[30
]}

Barbaro, Maria P. Foschino ^{[31
]}

Guarnieri, Gabriella ^{[32
]}

Guida, Giuseppe ^{[33
]}

Latorre, Manuela ^{[6
]}

Lo Cicero, Salvatore ^{[34
]}

Lombardi, Carlo ^{[35
]}

Macchia, Luigi ^{[36
]}

Mazza, Francesco ^{[21
]}

Menzella, Francesco ^{[37
]}

Milanese, Manlio ^{[38
]}

Montagni, Marcello ^{[39
]}

Montuschi, Paolo ^{[40
]}

Nucera, Eleonora ^{[41
]}

Parente, Roberta ^{[42
]}

Patella, Vincenzo ^{[43
]}

Pelaia, Girolamo ^{[44
]}

Pini, Laura ^{[45
]}

Puggioni, Francesca ^{[1
,2
]}

Ricciardi, Luisa ^{[46
]}

Ricciardolo, Fabio L. M. ^{[47
]}

Richeldi, Luca ^{[11
]}

机构：

[1] IRCCS, Humanitas Clin & Res Ctr, Personalized Med Asthma & Allergy, Rozzano, MI, Italy

[2] Humanitas Univ, Dept Biomed Sci, Pieve Emanuele, MI, Italy

[3] Univ Milan, Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Resp Unit, Milan, Italy

[4] Univ Milan, Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Adult Cyst Fibrosis Ctr, Milan, Italy

[5] Univ Milan, Fdn IRCCS Ca Granda, Osped Maggiore Policlin, Dept Pathophysiol & Transplantat, Milan, Italy

[6] Univ Pisa, Dept Surg Med Mol Biol & Crit Care, Pisa, Italy

[7] Univ Verona, Allergy Unit, Dept Med, Asthma Ctr, Verona, Italy

[8] Univ Genoa, IRCCS Policlin San Martino, Allergy & Resp Dis, Genoa, Italy

[9] Univ Insubria, ICS Maugeri, IRCCS, Varese, Italy

[10] ASL3, Resp Rehabil, Genoa, Italy

[11] IRCCS Catholic Univ Rome, Fdn Policlin Univ A Gemelli, Rome, Italy

[12] Univ Turin, Allergy & Clin Immunol, Turin, Italy

[13] AO Mauriziano, Turin, Italy

[14] Univ Turin, Dept Med Sci, Resp Med, Turin, Italy

[15] Univ Foggia, Sch & Chair Allergol & Clin Immunol, Dept Med Sci & Surg, Foggia, Italy

[16] Univ Campania L Vanvitelli, Dept Translat Med Sci, Naples, Italy

[17] Careggi Univ Hosp, Resp Unit, Dept Expt & Clin Biomed Sci Mario Serio, Florence, Italy

[18] Univ Bari Aldo Moro, Resp Med Sect, Dept Basic Med Sci Neurosci & Sense Organs, Policlin Bari, Bari, Italy

[19] IRCCS, Allergy Unit, Fdn Policlin A Gemelli, Rome, Italy

[20] Univ Milan, Resp Unit, Dept Hlth Sci, ASST Santi Paolo & Carlo, Milan, Italy

[21] Presidio Osped Pordenone, Resp Unit, Pordenone, Italy

[22] Univ Pavia, Fdn & Dept Internal Med & Therapeut, IRCCS Policlin San Matteo, Div Resp Dis, Pavia, Italy

[23] Univ Florence, Dept Expt & Clin Med, Florence, Italy

[24] Carlo Poma Hosp, Dept Med, Allergy & Clin Immunol Unit, Mantua, Italy

[25] Univ Catania, Policlin, Div Pneumol & Allergol, Catania, Italy

[26] Hosp Civitanova Marche, Allergol Unit, AV3 ASUR Marche, Macerata, Italy

[27] Univ Naples Federico II, Resp Dept, AO Colli, Div Resp Dis, Naples, Italy

[28] Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy

[29] Azienda USL Toscana Ctr, SOS Allergol & Clin Immunol, Prato, Italy

[30] Vittorio Veneto Hosp, Severe Asthma Multidisciplinary Outpatient Clin, Treviso, Italy

[31] Univ Foggia, Med & Surg Sci Dept, Sect Resp Dis, Foggia, Italy

[32] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, Padua, Italy

[33] AOS Croce & Carle, Allergy & Pneumol Unit, Cuneo, Italy

[34] Osped Niguarda Ca Granda, Dept Pneumol, Milan, Italy

[35] Hosp Inst Fdn Poliambulanza, Dept Unit Allergol & Pneumol, Brescia, Italy

[36] Univ Bari Aldo Moro, Sch & Chair Allergol & Clin Immunol, Dept Emergency & Organ Transplantat, Bari, Italy

[37] Santa Maria Nuova Hosp, Azienda USL Reggio Emilia IRCCS, Pneumol Unit, Florence, Italy

[38] ASL2 Savonese, Pulmonol Unit, Pietra Ligure, Savona, Italy

[39] UOC Allergol Dept, Piacenza, Italy

[40] Fdn Policlin Univ A Gemelli IRCCS, Univ Sacred Heart, Fac Med Catholic, Dept Pharmacol, Rome, Italy

[41] Fdn Policlin Univ A Gemelli IRCCS, Catholic Univ S Heart, Rome, Italy

[42] Univ Salerno, Div Allergy & Clin Immunol, Dept Med, Salerno, Italy

[43] Santa Maria Speranza Hosp Battipaglia, Dept Med Sci, Allergol & Clin Immunol Unit, Salerno, Italy

[44] Magna Graecia Univ Catanzaro, Sect Resp Dis, Dept Med & Surg Sci, Catanzaro, Italy

[45] Univ Brescia, Dept Clin & Expt Sci, Spedali Civili, Brescia, Italy

[46] Univ Messina, Univ Hosp G Martino, Dept Clin & Expt Med, Allergy & Clin Immunol Unit, Messina, Italy

[47] Univ Turin, San Luigi Hosp, Dept Clin & Biol Sci, Turin, Italy

[48] Univ Parma, Dept Med & Surg, Parma, Italy

[49] Univ Milan, Sacco Univ Hosp, Dept Clin & Biomed Sci, ASST Fatebenefratelli Sacco,Resp Dis, Milan, Italy

[50] Univ Palermo, Dept Promoting Hlth Maternal Infant Excellence &, Div Resp Dis, Palermo, Italy

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2020年 / 13卷 / 10期

关键词：

Severe asthma; Biologics; Oral corticosteroids; Real-life; Registr; OMALIZUMAB; MEPOLIZUMAB; DEFINITION;

D O I：

10.1016/j.waojou.2020.100464

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored all alternatives currently available for a large part of severe asthmatics.

引用

页数：9

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