Norfloxacin-Incorporated Polymeric Micelle Composed of Poly(ε-caprolactone)/Poly(ethylene glycol) Diblock Copolymer

We prepared norfloxacin (NFX)-incorporated polymeric micelle using poly (c-caprolactone)/poly(ethylene glycol) (PCL/PEG, CE) diblock copolymers. Particle size was from 60 to 200 nm according to the PCL block length. Their critical association concentration (CAC) was decreased according to the increase of PCL block length. H-1-NMR study showed core-shell type micelle structures of CE diblock copolymers in the aqueous environment. Drug release from polymeric micelle was continued over 2 days. Duration of drug release was varied according to the PCL block length and drug contents. At antimicrobial activity test, polymeric micelle showed almost similar cytotoxicity compared to NFX itself.