MT1-MMP-dependent cell migration: proteolytic and non-proteolytic mechanisms

被引：63
|
作者：
Gifford, Valentina [1 ]
Itoh, Yoshifumi [1 ]
机构：
[1] Univ Oxford, Kennedy Inst Rheumatol, Oxford, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2019年 / 47卷
基金：
英国医学研究理事会;
关键词：
TYPE-1; MATRIX-METALLOPROTEINASE; GELATINASE-A ACTIVATION; EXTRACELLULAR-MATRIX; TISSUE INHIBITOR; CYTOPLASMIC TAIL; TUMOR INVASION; 3-DIMENSIONAL INVASION; PROMMP-2; ACTIVATION; MEDIATED REGULATION; MT1-MMP EXPRESSION;
D O I：
10.1042/BST20180363
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a type I transmembrane proteinase that belongs to the matrix metalloproteinase (MMP) family. It is a potent modifier of cellular microenvironment and promotes cell migration and invasion of a wide variety of cell types both in physiological and pathological conditions. It promotes cell migration by degrading extracellular matrix on the cell surface and creates a migration path, by modifying cell adhesion property by shedding cell adhesion molecules to increase cell motility, and by altering cellular metabolism. Thus, MT1-MMP is a multifunctional cell motility enhancer. In this review, we will discuss the current understanding of the proteolytic and non-proteolytic mechanism of MT1-MMP-dependent cell migration.
引用
收藏
页码：811 / 826
页数：16
相关论文
共 50 条
  • [1] Genetic dissection of proteolytic and non-proteolytic contributions of MT1-MMP to macrophage invasion
    Hara, Toshiro
    Mimura, Kouhei
    Seiki, Motoharu
    Sakamoto, Takeharu
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 413 (02) : 277 - 281
  • [2] Extracellular matrix determinants of proteolytic and non-proteolytic cell migration
    Wolf, Katarina
    Friedl, Peter
    [J]. TRENDS IN CELL BIOLOGY, 2011, 21 (12) : 736 - 744
  • [3] Non-proteolytic function of MT1-MMP regulates the tumor microenvironments
    Sakamoto, Takeharu
    [J]. CANCER SCIENCE, 2018, 109 : 67 - 67
  • [4] Proteolytic and non-proteolytic migration of tumour cells and leucocytes
    Friedl, P
    Wolf, K
    [J]. PROTEASES AND THE REGULATION OF BIOLOGICAL PROCESSES, 2003, 70 : 277 - 285
  • [5] Proteolytic and non-proteolytic functions of MMP9 in cancer invasion
    Dutta, Sarbajeet
    Ghosh, Swetlana
    Sen, Shamik
    [J]. BIOPHYSICAL JOURNAL, 2024, 123 (03) : 2A - 2A
  • [6] Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion
    Castro-Castro, Antonio
    Marchesin, Valentina
    Monteiro, Pedro
    Lodillinsky, Catalina
    Rosse, Carine
    Chavrier, Philippe
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 32, 2016, 32 : 555 - 576
  • [7] Proteolytic and non-proteolytic activation of prorenin
    Reudelhuber, TL
    Brechler, V
    Jutras, I
    Mercure, C
    Methot, D
    [J]. ASPARTIC PROTEINASES: RETROVIRAL AND CELLULAR ENZYMES, 1998, 436 : 229 - 238
  • [8] Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization
    Kumar, Sandeep
    Kapoor, Aastha
    Desai, Sejal
    Inamdar, Mandar M.
    Sen, Shamik
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [9] Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization
    Kumar, S.
    Inamdar, M.
    Sen, S.
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2015, 26
  • [10] Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization
    Sandeep Kumar
    Aastha Kapoor
    Sejal Desai
    Mandar M. Inamdar
    Shamik Sen
    [J]. Scientific Reports, 6
12345