Microbial production of 1α-hydroxyvitamin D3 from vitamin D3

被引：3
|
作者：
Ahmed, Safwat A. [1 ]
Mesbah, Mostafa K. [2 ]
Youssef, Diaa T. [3 ]
Khalifa, Sherief I. [4 ]
机构：
[1] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia, Egypt
[2] Sinai Univ, Dept Pharmacognosy, Fac Pharm, North Sinai 55441, Egypt
[3] King Abdulaziz Univ, Dept Nat Prod, Fac Pharm, Jeddah 21589, Saudi Arabia
[4] Qatar Univ, Coll Pharm, Doha 02713, Qatar
来源：
NATURAL PRODUCT RESEARCH | 2014年 / 28卷 / 07期
关键词：
1 alpha-hydroxyvitamin D3; renal failure; Candida maltosa R42; Botrytis allii NRRL 2502; vitamin D3; SP STRAINS; TRANSFORMATION; 25-HYDROXYVITAMIN-D3;
D O I：
10.1080/14786419.2013.872104
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The microbial transformation of vitamin D-3 (1) by the fungi Candida maltosa R42 and Botrytis allii NRRL 2502 was investigated. Incubation of compound 1 with C. maltosa R42 and B. allii NRRL 2502 produced the same three more polar metabolites in small yields. The main metabolite was identified as 1 alpha-hydroxyvitamin D-3 (2). This biotransformation has utility as a possible tool for the production of 1 alpha-hydroxyvitamin D-3 from the readily available vitamin D-3 for patients with compromised kidney function.
引用
收藏
页码：444 / 448
页数：5
相关论文
共 50 条
  • [1] Vitamin D3, 25-Hydroxyvitamin D3, and Food Fortification
    Hill, Tom R.
    Kyriazakis, Ilias
    [J]. JOURNAL OF NUTRITION, 2018, 148 (04): : 664 - 665
  • [2] Transdermal sampling of vitamin D3 and 25-hydroxyvitamin D3
    Mall, Isaac
    Musteata, Florin Marcel
    [J]. BIOANALYSIS, 2019, 11 (02) : 61 - +
  • [3] Vitamin D3, 25-Hydroxyvitamin D3, and 1α-Hydroxyvitamin D3 Modulate Fiber Type Distribution in Bicep Femoris of Growing Rats
    Park, Min Young
    Kim, Jonggun
    Whang, Kwang-Youn
    [J]. FASEB JOURNAL, 2015, 29
  • [4] Vitamin D3, 25-Hydroxyvitamin D3, and Food Fortification Reply
    Guo, Jing
    Jackson, Kim G.
    Givens, David I.
    Lovegrove, Julie A.
    [J]. JOURNAL OF NUTRITION, 2018, 148 (04): : 665 - 665
  • [5] Human keratinocyte line HaCaT metabolizes 1α-hydroxyvitamin D3 and vitamin D3 to 1α,25-dihydroxyvitamin D3 (calcitriol)
    Lehmann, B
    Pietzsch, J
    Kampf, A
    Meurer, M
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 1998, 18 (02) : 118 - 127
  • [6] The ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 is predictive of 25-hydroxyvitamin D3 response to vitamin D3 supplementation
    Wagner, Dennis
    Hanwell, Heather E.
    Schnabl, Kareena
    Yazdanpanah, Mehrdad
    Kimball, Samantha
    Fu, Lei
    Sidhom, Gloria
    Rousseau, Derick
    Cole, David E. C.
    Vieth, Reinhold
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2011, 126 (3-5): : 72 - 77
  • [7] Vitamin D3 and 25-hydroxyvitamin D3 in raw and cooked pork cuts
    Clausen, I
    Jakobsen, J
    Leth, T
    Ovesen, L
    [J]. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 2003, 16 (05) : 575 - 585
  • [8] Synthesis of 24(28)-methylene-1α-hydroxyvitamin D3, a novel vitamin D3 analogue
    Guo, Wei
    Fang, Zhijie
    Li, Hongliang
    Liu, Yanan
    [J]. JOURNAL OF CHEMICAL RESEARCH, 2014, (04) : 231 - 235
  • [9] Safety of 25-hydroxyvitamin D3 as a source of vitamin D3 in turkey rations
    Lanenga, M
    Terry, M
    McNaughton, JL
    Stark, LE
    [J]. VETERINARY AND HUMAN TOXICOLOGY, 1999, 41 (02) : 75 - 78
  • [10] A new method for the determination of vitamin D3 and 25-hydroxyvitamin D3 in meat
    Jakobsen, J
    Clausen, I
    Leth, T
    Ovesen, L
    [J]. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, 2004, 17 (06) : 777 - 787
12345