PENALIZED LIKELIHOOD FOR LOGISTIC-NORMAL MIXTURE MODELS WITH UNEQUAL VARIANCES

被引:3
|
作者
Shen, Juan [1 ]
Wang, Yingchuan [2 ]
He, Xuming [2 ]
机构
[1] Fudan Univ, Dept Stat, Shanghai 200433, Peoples R China
[2] Univ Michigan, Dept Stat, 1085 South Univ, Ann Arbor, MI 48109 USA
基金
中国国家自然科学基金; 美国国家科学基金会;
关键词
EM algorithm; heterogeneous components; homogeneity test; likelihood ratio test; mixture models; subgroup identification; SUBGROUP IDENTIFICATION; CLINICAL-TRIALS; EM ALGORITHM; BIOMARKERS;
D O I
10.5705/ss.202015.0371
中图分类号
O21 [概率论与数理统计]; C8 [统计学];
学科分类号
020208 ; 070103 ; 0714 ;
摘要
Subgroup analysis with unspecified subgroup memberships has received increasing attention in recent years. In Shen and He (2015), a structured logistic normal mixture model was proposed to characterize the subgroup distributions and the subgroup membership simultaneously, but under the assumption that the subgroups differ only in the means. In this paper, we consider a penalized likelihood approach for more general cases with heterogeneous subgroup variances. Despite substantial technical complications in the development of the statistical theory, we show that the penalized likelihood inference for the existence of subgroups and for the estimation of subgroup membership can be carried out in the existing framework. Empirical results with a simulation study and two data examples demonstrate the usefulness of the proposed method.
引用
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页码:711 / 731
页数:21
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