Effect of Complete Maternal and Littermate Deprivation on Morphine-Induced Fos-Immunoreactivity in the Adult Male Rat Brain

被引：3

作者：

Rana, Shadna A. ^{[1
]}

Mallet, Paul E. ^{[2
]}

Robertson, Barbara-Anne ^{[1
]}

Wainwright, Patricia E. ^{[1
]}

机构：

[1] Univ Waterloo, Dept Hlth Studies & Gerontol, Waterloo, ON N2L 3G1, Canada

[2] Wilfrid Laurier Univ, Dept Psychol, Waterloo, ON N2L 3C5, Canada

来源：

PEDIATRIC RESEARCH | 2010年 / 67卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

BEHAVIORAL-RESPONSES; DRUG-USE; EXPRESSION; SEPARATION; STRESS; ALTERS; IMPACT; ABUSE; ENVIRONMENT; MODULATION;

D O I：

10.1203/PDR.0b013e3181ca0807

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Previous research has demonstrated that rats reared in isolation from their dam and littermates show altered behavioral responsiveness to both natural and drug-mediated rewards. This study examined the effects of complete maternal deprivation through the use of artificial rearing on neural activation after acute morphine exposure in adulthood. Male rats were either artificially reared (AR) or maternally reared (MR) from postnatal day 5 to 21. In adulthood (4 mo old), rats received a single injection of morphine sulfate (10 mg/kg) or equivolume saline 2 h before perfusion and brain extraction. Neural activation was quantified using Fos immunohistochemistry. Analyses of several brain regions revealed a consistent pattern of differences between AR and MR rats. Specifically, relative to MR rats, AR rats showed significantly greater morphine-induced Fos-immunoreactivity in brain regions associated with the mesocorticolimbic "reward" pathway. These results Support the hypothesis that functional activity in reward neurocircuitry can be altered by early life experience. (Pediatr Res 67: 263-267, 2010)

引用

页码：263 / 267

页数：5

共 18 条

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Paul E Mallet
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Patricia E Wainwright
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