The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

被引：252
|
作者：
Zhou, Pingting [1 ]
Li, Bo [2 ]
Liu, Furao [1 ]
Zhang, Meichao [1 ]
Wang, Qian [1 ]
Liu, Yuanhua [3 ]
Yao, Yuan [4 ]
Li, Dong [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oncol, Shanghai, Peoples R China
[2] Second Mil Med Univ, Changzheng Hosp, Dept Bone Tumor Surg, Shanghai, Peoples R China
[3] Nanjing Med Univ, Affiliated Canc Hosp, Canc Inst Jiangsu Prov, Dept Chemotherapy, Nanjing, Jiangsu, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Radiat Oncol, Shanghai, Peoples R China
来源：
MOLECULAR CANCER | 2017年 / 16卷
基金：
中国国家自然科学基金;
关键词：
Pancreatic cancer; Cancer stem cell; Epithelial-to-mesenchymal transition; Resistance; GROWTH-FACTOR-BETA; E-CADHERIN; MIR-200; FAMILY; SIDE POPULATION; FEEDBACK LOOP; SELF-RENEWAL; REGULATORY NETWORKS; TUMOR PROGRESSION; INITIATING CELLS; DRUG-RESISTANCE;
D O I：
10.1186/s12943-017-0624-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective of therapy. In particular, pancreatic cancer stem cells (PCSCs) are functionally important during tumor relapse and therapy resistance. In this review we have surveyed recent advances in the role of EMT and PCSCs in tumor progression, metastasis and treatment resistance, and the mechanisms of integrated with biochemical signals and the underlying pathways involved in treatment resistance of pancreatic cancer. These findings highlight the importance of confirming stem-cells markers and complex molecular signaling pathways controlling EMT and cancer stem cells in pancreatic cancer during tumor formation, progression, and response to therapy.
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页数：11
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