Metal-free, high yielding synthesis of unsymmetrical biaryl, bi(heteroaryl), aryl vinyl, aryl alkyl sulfones via coupling of aryne with sulfinic acid salts

被引：26
|
作者：
Aithagani, Sravan Kumar [1 ,2 ]
Yempalla, Kushalava Reddy [1 ,2 ]
Munagala, Gurunadham [1 ,2 ]
Vishwakarma, Ram A. [1 ,2 ]
Singh, Parvinder Pal [1 ,2 ]
机构：
[1] CSIR, Indian Inst Integrat Med, Div Med Chem, Jammu 180001, India
[2] CSIR, Indian Inst Integrat Med, Acad Sci & Innovat Res, Jammu 180001, India
来源：
RSC ADVANCES | 2014年 / 4卷 / 91期
关键词：
DIARYL SULFONES; RECEPTOR; SULFONYLATION; INHIBITORS; LIGANDS; IODIDES; HALIDES; RING;
D O I：
10.1039/c4ra07370c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Here, we report ametal-free, high yieldingmethod for the synthesis of unsymmetrical biaryl sulfones via coupling of aryne with sulfinic acid salts. The optimized condition also works efficiently for bi(heteroaryl), aryl vinyl and aryl alkyl sulfones. The present method took comparatively shorter reaction times and has good functional group compatibility.
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收藏
页码：50208 / 50211
页数：4
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