Dominantly Inherited Alzheimer Network: facilitating research and clinical trials

被引：112
|
作者：
Moulder, Krista L. [1 ]
Snider, B. Joy [1 ]
Mills, Susan L. [1 ]
Buckles, Virginia D. [1 ]
Santacruz, Anna M. [1 ]
Bateman, Randall J. [1 ]
Morris, John C. [1 ]
机构：
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63108 USA
来源：
ALZHEIMERS RESEARCH & THERAPY | 2013年 / 5卷 / 05期
关键词：
ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; COGNITIVE IMPAIRMENT; ENTORHINAL CORTEX; A-BETA; DISEASE; PRESENILIN-1; ONSET; RECOMMENDATIONS;
D O I：
10.1186/alzrt213
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The Dominantly Inherited Alzheimer Network (DIAN) is an international registry of individuals at risk for developing autosomal dominant Alzheimer's disease (AD). Its primary aims are to investigate the temporal ordering of AD pathophysiological changes that occur in asymptomatic mutation carriers and to identify those markers that herald the transition from cognitive normality to symptomatic AD. DIAN participants undergo longitudinal evaluations, including clinical and cognitive assessments and measurements of molecular and imaging AD biomarkers. This review details the unique attributes of DIAN as a model AD biomarker study and how it provides the infrastructure for innovative research projects, including clinical trials. The recent design and launch of the first anti-amyloid-beta secondary prevention trial in AD, led by the related DIAN Trials Unit, also are discussed.
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页数：7
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