A comparison of pharmacokinetic models of dynamic contrast enhanced MRI

被引：14
|
作者：
Srikanchana, R [1 ]
Thomasson, D [1 ]
Choyke, P [1 ]
Dwyer, A [1 ]
机构：
[1] NCI, Bethesda, MD 20892 USA
来源：
17TH IEEE SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS, PROCEEDINGS | 2004年
关键词：
D O I：
10.1109/CBMS.2004.1311740
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
Dynamic Contrast Enhanced MRI (DCE-MRI) is often employed as an indicator of drug activity in clinical trials of angiogenic inhibitors. The data obtained with DCE-MRI is reported semi quantitatively using parameters derived from pharmacokinetic models. Most MPI kinetic models were developed from Nuclear Medicine quantitative studies but the limitations of MRI dictated specific modifications. A number of these MRI models are in current use. In this work, we review several pharmacokinetic models used in DCE-MRI in order to determine the most appropriate model to assess tumor angiogenesis. These models are compared with respect to their physiological appropriateness; compartmental analysis; initial and boundary conditions; and clinically relevant output parameters.
引用
收藏
页码：361 / 366
页数：6
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