A comparison of pharmacokinetic models of dynamic contrast enhanced MRI

被引：14

作者：

Srikanchana, R ^{[1
]}

Thomasson, D ^{[1
]}

Choyke, P ^{[1
]}

Dwyer, A ^{[1
]}

机构：

[1] NCI, Bethesda, MD 20892 USA

来源：

17TH IEEE SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS, PROCEEDINGS | 2004年

关键词：

D O I：

10.1109/CBMS.2004.1311740

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Dynamic Contrast Enhanced MRI (DCE-MRI) is often employed as an indicator of drug activity in clinical trials of angiogenic inhibitors. The data obtained with DCE-MRI is reported semi quantitatively using parameters derived from pharmacokinetic models. Most MPI kinetic models were developed from Nuclear Medicine quantitative studies but the limitations of MRI dictated specific modifications. A number of these MRI models are in current use. In this work, we review several pharmacokinetic models used in DCE-MRI in order to determine the most appropriate model to assess tumor angiogenesis. These models are compared with respect to their physiological appropriateness; compartmental analysis; initial and boundary conditions; and clinically relevant output parameters.

引用

页码：361 / 366

页数：6

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