Non-Coding RNAs and Hereditary Hemorrhagic Telangiectasia

被引：7
|
作者：
Cannavicci, Anthony [1 ,2 ]
Zhang, Qiuwang [2 ]
Kutryk, Michael J. B. [1 ,2 ]
机构：
[1] Univ Toronto, Inst Med Sci, Toronto, ON M5S 1A8, Canada
[2] Univ Toronto, Keenan Res Ctr Biomed Sci, Div Cardiol, St Michaels Hosp,Unity Hlth Toronto, Toronto, ON M5B 1T8, Canada
来源：
JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 10期
基金：
美国国家卫生研究院;
关键词：
non-coding RNAs; microRNAs; long non-coding RNAs; hereditary hemorrhagic telangiectasia; biomarkers; endothelial cells; angiogenesis; SMOOTH-MUSCLE-CELLS; ENDOTHELIAL-CELLS; CIRCULATING MICRORNAS; ARTERIOVENOUS-MALFORMATIONS; SIGNALING PATHWAYS; GENE; BIOMARKERS; DIAGNOSIS; CANCER; GROWTH;
D O I：
10.3390/jcm9103333
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Non-coding RNAs (ncRNAs) are functional ribonucleic acid (RNA) species that include microRNAs (miRs), a class of short non-coding RNAs (similar to 21-25 nucleotides), and long non-coding RNAs (lncRNAs) consisting of more than 200 nucleotides. They regulate gene expression post-transcriptionally and are involved in a wide range of pathophysiological processes. Hereditary hemorrhagic telangiectasia (HHT) is a rare disorder inherited in an autosomal dominant fashion characterized by vascular dysplasia. Patients can develop life-threatening vascular malformations and experience severe hemorrhaging. Effective pharmacological therapies are limited. The study of ncRNAs in HHT is an emerging field with great promise. This review will explore the current literature on the involvement of ncRNAs in HHT as diagnostic and pathogenic factors.
引用
收藏
页码：1 / 14
页数：14
相关论文
共 50 条
  • [1] Genome Sequencing Reveals Variants in Non-Coding Regions Cause Hereditary Hemorrhagic Telangiectasia
    Tayfun, G. Akay
    Wooderchak-Donahue, W.
    Johnson, P. A.
    McDonald, J. A.
    Bayrak-Toydemir, P. A.
    [J]. JOURNAL OF MOLECULAR DIAGNOSTICS, 2017, 19 (06): : 948 - 949
  • [2] Non-Coding RNAs in Hereditary Kidney Disorders
    Zhou, Julie Xia
    Li, Xiaogang
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (06) : 1 - 19
  • [3] Bladder cancer: non-coding RNAs and exosomal non-coding RNAs
    Zhao, Jingang
    Ma, Yangyang
    Zheng, Xiaodong
    Sun, Zhen
    Lin, Hongxiang
    Du, Chuanjun
    Cao, Jing
    [J]. FUNCTIONAL & INTEGRATIVE GENOMICS, 2024, 24 (05)
  • [4] Non-coding RNAs and exosomal non-coding RNAs in pituitary adenoma
    Rahimian, Neda
    Sheida, Amirhossein
    Rajabi, Mohammadreza
    Heidari, Mohammad Mahdi
    Tobeiha, Mohammad
    Esfahani, Pegah Veradi
    Asouri, Sahar Ahmadi
    Hamblin, Michael R.
    Mohamadzadeh, Omid
    Motamedzadeh, Alireza
    Mahabady, Mahmood Khaksary
    [J]. PATHOLOGY RESEARCH AND PRACTICE, 2023, 248
  • [5] The role of long non-coding RNAs in the pathogenesis of hereditary diseases
    Sparber, Peter
    Filatova, Alexandra
    Khantemirova, Mira
    Skoblov, Mikhail
    [J]. BMC MEDICAL GENOMICS, 2019, 12 (Suppl 2)
  • [6] Coding in non-coding RNAs
    Waterhouse, Peter M.
    Hellens, Roger P.
    [J]. NATURE, 2015, 520 (7545) : 41 - 42
  • [7] The role of long non-coding RNAs in the pathogenesis of hereditary diseases
    Peter Sparber
    Alexandra Filatova
    Mira Khantemirova
    Mikhail Skoblov
    [J]. BMC Medical Genomics, 12
  • [8] Coding in non-coding RNAs
    Peter M. Waterhouse
    Roger P. Hellens
    [J]. Nature, 2015, 520 : 41 - 42
  • [9] Long Non-Coding RNA Expression Profiles in Hereditary Haemorrhagic Telangiectasia
    Torring, Pernille M.
    Larsen, Martin Jakob
    Kjeldsen, Anette D.
    Ousager, Lilian Bomme
    Tan, Qihua
    Brusgaard, Klaus
    [J]. PLOS ONE, 2014, 9 (03):
  • [10] Long non-coding rna expression profiles in hereditary haemorrhagic telangiectasia
    Torring, P. M.
    Larsen, M. J.
    Kjeldsen, A. D.
    Ousager, L. B.
    Tan, Q.
    Brusgaard, K.
    [J]. ANGIOGENESIS, 2015, 18 (04) : 569 - 569
12345