Associations between body size, nutrition and socioeconomic position in early life and the epigenome: A systematic review

被引:8
|
作者
Maddock, Jane [1 ]
Wulaningsih, Wahyu [1 ]
Fernandez, Juan Castillo [2 ]
Ploubidis, George B. [3 ]
Goodman, Alissa [3 ]
Bell, Jordana [2 ]
Kuh, Diana [1 ]
Hardy, Rebecca [1 ]
机构
[1] UCL, Inst Cardiovasc Sci, MRC Unit Lifelong Hlth & Ageing, London, England
[2] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
[3] UCL, UCL Inst Educ, Ctr Longitudinal Studies, London, England
来源
PLOS ONE | 2018年 / 13卷 / 08期
基金
英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
FOLIC-ACID SUPPLEMENTATION; OFFSPRING DNA METHYLATION; BIRTH-WEIGHT DISCORDANCE; UMBILICAL-CORD BLOOD; IGF1; P2; PROMOTER; GESTATIONAL-AGE; ADULT HEALTH; PLASMA HOMOCYSTEINE; PRENATAL EXPOSURE; WIDE ASSOCIATION;
D O I
10.1371/journal.pone.0201672
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Body size, nutrition and socioeconomic position (SEP) in early life have been associated with a wide range of long-term health effects. Epigenetics is one possible mechanism through which these early life exposures can impact later life health. We conducted a systematic review examining the observational evidence for the impact of body size, nutrition and SEP in early life on the epigenome in humans. Methods This systematic review is registered with the PROSPERO database (registration number: CRD42016050193). Three datasets were simultaneously searched using Ovid and the resulting studies were evaluated by at least two independent reviewers. Studies measuring epigenetic markers either at the same time as, or after, the early life exposure and have a measure of body size, nutrition or SEP in early life (up to 12 years), written in English and from a community-dwelling participants were included. Results We identified 90 eligible studies. Seventeen of these papers examined more than one early life exposure of interest. Fifty six papers examined body size, 37 nutrition and 17 SEP. All of the included papers examined DNA methylation (DNAm) as the epigenetic marker. Overall there was no strong evidence for a consistent association between these early life variables in DNAm which may be due to the heterogeneous study designs, data collection methods and statistical analyses. Conclusions Despite these inconclusive results, the hypothesis that the early life environment can impact DNAm, potentially persisting into adult life, was supported by some studies and warrants further investigation. We provide recommendations for future studies.
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页数:48
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