Application of routine electronic health record databases for pharmacogenetic research

被引：4

作者：

Yasmina, A. ^{[1
,2
]}

Deneer, V. H. M. ^{[3
]}

Maitland-van der Zee, A. H. ^{[1
]}

van Staa, T. P. ^{[1
,4
]}

de Boer, A. ^{[1
]}

Klungel, O. H. ^{[1
]}

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands

[2] Lambung Mangkurat Univ, Dept Pharmacol & Therapeut, Fac Med, Banjarmasin, Indonesia

[3] St Antonius Hosp, Dept Clin Pharm, Nieuwegein, Netherlands

[4] London Sch Hyg & Trop Med, London WC1, England

来源：

JOURNAL OF INTERNAL MEDICINE | 2014年 / 275卷 / 06期

基金：

英国医学研究理事会;

关键词：

electronic health records; pharmacogenetics; GENE-ENVIRONMENT INTERACTION; ADVERSE CLINICAL-OUTCOMES; CARDIOVASCULAR-DISEASE; CYP2C19; GENOTYPE; TREATED PATIENTS; RISK; POLYMORPHISMS; DESIGNS; TRIAL; CYP2C19-ASTERISK-2;

D O I：

10.1111/joim.12226

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Inter-individual variability in drug responses is a common problem in pharmacotherapy. Several factors (non-genetic and genetic) influence drug responses in patients. When aiming to obtain an optimal benefit-risk ratio of medicines and with the emergence of genotyping technology, pharmacogenetic studies are important for providing recommendations on drug treatments. Advances in electronic healthcare information systems can contribute to increasing the quality and efficiency of such studies. This review describes the definition of pharmacogenetics, gene selection and study design for pharmacogenetic research. It also summarizes the potential of linking pharmacoepidemiology and pharmacogenetics (along with its strengths and limitations) and provides examples of pharmacogenetic studies utilizing electronic health record databases.

引用

页码：590 / 604

页数：15

共 50 条

[1] Ecosystem of Electronic Health Record Databases in Venezuela
Clotet, R.
Hernandez, E.
Huerta, M.
Rivas, D.
[J]. VI LATIN AMERICAN CONGRESS ON BIOMEDICAL ENGINEERING (CLAIB 2014), 2014, 49 : 809 - 812
[2] Semantic Interoperability in Standardized Electronic Health Record Databases
Sachdeva, Shelly
Bhalla, Subhash
[J]. ACM JOURNAL OF DATA AND INFORMATION QUALITY, 2012, 3 (01): : 1 - 37
[3] Information interchange services for electronic health record databases
Sachdeva, Shelly
Madaan, Aastha
Chu, Wanming
[J]. INTERNATIONAL JOURNAL OF COMPUTATIONAL SCIENCE AND ENGINEERING, 2012, 7 (01) : 38 - 51
[4] POWERFORM FOR REAL-TIME ENTRY OF ROUTINE CARDIAC OUTPATIENT DATA INTO THE ELECTRONIC HEALTH RECORD: APPLICATION FOR AUDIT AND RESEARCH
Bodagh, Neil
Archbold, Andrew
Weerackody, Roshan
Barnes, Mike
Robson, John
Timmis, Adam
[J]. HEART, 2017, 103 : A74 - A75
[5] Automated electronic health record-based application for sedation triage in routine colonoscopy
Garg, Sushil Kumar
Szymoniak, Amy M.
Johnson, Karen F.
Vaughn, Jackqueline K.
Seelman, John J.
Degen, Susanne C.
Chaudhry, Rajeev
[J]. GASTROINTESTINAL ENDOSCOPY, 2023, 98 (01) : 82 - 89.e1
[6] Integrating pharmacogenetic information and clinical decision support into the electronic health record
Goldspiel, Barry R.
Flegel, Willy A.
DiPatrizio, Gary
Sissung, Tristan
Adams, Sharon D.
Penzak, Scott R.
Biesecker, Leslie G.
Fleisher, Thomas A.
Patel, Jharana J.
Herion, David
Figg, William D.
Lertora, Juan J. L.
McKeeby, Jon W.
[J]. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2014, 21 (03) : 522 - 528
[7] Electronic Health Record Assists in Routine HIV Screening
Voelker, Rebecca
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2014, 312 (08): : 781 - 781
[8] Electronic health record databases provide a platform for intervention studies
Csonka, Peter
Korppi, Matti
[J]. ACTA PAEDIATRICA, 2022, 111 (06) : 1104 - 1106
[9] Using an Electronic Health Record for Research
Goldwein, Joel
[J]. JOURNAL OF ONCOLOGY PRACTICE, 2007, 3 (05) : 278 - 279
[10] The Electronic Health Record for Translational Research
Luke V. Rasmussen
[J]. Journal of Cardiovascular Translational Research, 2014, 7 : 607 - 614

← 1 2 3 4 5 →