Expression of nm23 and tenascin in invasive ductal carcinomas of the breast

被引：0
|
作者：
Kaya, H [1 ]
Hücümenoglu, S
Bozkurt, SU
Ekicioglu, G
Kotiloglu, E
机构：
[1] Marmara Univ Hosp, Dept Pathol, TR-81190 Istanbul, Turkey
[2] SSK Ankara Training Hosp, Ankara, Turkey
来源：
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY | 2002年 / 23卷 / 03期
关键词：
tenascin; nm23; expression; ductal carcinoma; breast;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: In this series of ductal carcinoma of the breast, immunoexpression of antimetastasis gene nm23 and tenascin was examined and the role in prognosis was investigated by correlation with the tumour grade and stage, and ER/PR immunoexpression. Material and Methods: In this Study 27 ductal carcinomas of the breast, ere analysed for expression of tenascin and nm23 antimetastasis genes by immunohistochemistry. Results: The results Of our Study revealed a statistically significant cot-relation between nm23-H1 immunoexpression and lymph node metastasis. We also found a statistically significant correlation between tenascin and nm23-H1 immunoexpression. Our results suggest that tenascin limits tumour spread. Conclusion(s): Antimetastasis gene expression can be used in predicting lymph node metastasis in ductal carcinomas of the breast.
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页码：261 / +
页数：4
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