Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane

被引：6
|
作者：
Battisti, Umberto Maria [1 ]
Sorbi, Claudia [1 ]
Franchini, Silvia [1 ]
Tait, Annalisa [1 ]
Brasili, Livio [1 ]
机构：
[1] Univ Modena & Reggio Emilia, Dept Life Sci, I-41125 Modena, Italy
来源：
SYNTHESIS-STUTTGART | 2014年 / 46卷 / 07期
关键词：
butane-1,2,4-triol; transacetalization; regioselective; stereoselective; cobalt chloride; chlorotrimethylsilane;
D O I：
10.1055/s-0033-1340662
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Transacetalization of acetals with butane-1,2,4-triol was carried out using cobalt(II) chloride and chlorotrimethylsilane as catalysts. The reaction occurs under mild conditions in acetonitrile and with a short reaction time. The synergic effect of the two Lewis acids catalyzes the conversion of butane-1,2,4-triol into (2-alkyl- or 2-aryl-1,3-dioxan-4-yl)methanol derivatives with high regiospecificity and diasteroselectivity.
引用
收藏
页码：943 / 946
页数：4
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