Studies on Icariin by electrospray ionization mass spectrometry

被引：0
|
作者：
Dou, JP [1 ]
Liu, ZQ [1 ]
Liu, SY [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, New Drug Res Labs, Changchun 130022, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2004年 / 25卷 / 05期
关键词：
Icariin; electrospray ionization; mass spectrometry; H/D exchange;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrospray ionization mass spectrometry (ESI-MS) in both the positive and the negative ion modes has been used to analyze Icariin(Anhydroicaritin-3-O-alpha-L-rhamnoside-7-O-beta-D-glucopyranoside). The results show that strong peak of [M+2H(2)O-H](-) in the negative ion mode was readily observed. Through an experimental method of hydrogen and deuterium exchange, it is proved that the two H2O is crystal water of Icariin. The collision-induced dissociation fragmentation pathways are different in the positive and the negative ion mode and they are proposed.
引用
收藏
页码：837 / 840
页数：4
相关论文
共 14 条
  • [1] BODDEKER P, 1995, PHARM PHARM LETT, V2, P91
  • [2] Chen ML, 2002, CHEM J CHINESE U, V23, P805
  • [3] Cui M, 2000, RAPID COMMUN MASS SP, V14, P1280, DOI 10.1002/1097-0231(20000730)14:14<1280::AID-RCM26>3.0.CO
  • [4] 2-C
  • [5] Cui M, 2001, CHEM J CHINESE U, V22, P1323
  • [6] JI H, 2000, J CHINA PHARM U, V31, P222
  • [7] Liu CM, 1995, J SHENYANG PHARM U, V12, P192
  • [8] Liu TH, 2000, CHIN TRAD HERBAL DRU, V31, P834
  • [9] Internal glucose residue loss in protonated O-diglycosyl flavonoids upon low-energy collision-induced dissociation
    Ma, YL
    Vedernikova, I
    Van den Heuvel, H
    Claeys, M
    [J]. JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2000, 11 (02) : 136 - 144
  • [10] Qiu Feng, 1999, Acta Pharmaceutica Sinica, V34, P222
12