Anticancer effect of docetaxel/hydroxypropyl-beta-cyclodextrin complex without histamine release

被引：3
|
作者：
Kim, Tae Kon [1 ]
Yoo, Hye Hyun [2 ,3 ]
机构：
[1] Jungwon Univ, Coll Sci & Engn, Chungbuk 367700, South Korea
[2] Hanyang Univ, Inst Pharmaceut Sci & Technol, Ansan 426791, Gyeonggi Do, South Korea
[3] Hanyang Univ, Coll Pharm, Ansan 426791, Gyeonggi Do, South Korea
来源：
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 2015年 / 83卷 / 3-4期
基金：
新加坡国家研究基金会;
关键词：
Docetaxel; HP-beta-CD; Anticancer activity; Hypersensitivity; DOCETAXEL FORMULATION; TAXOTERE; SID530; PHARMACOKINETICS; BINDING; SAFETY; PLASMA;
D O I：
10.1007/s10847-015-0571-2
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, the anticancer effect and improved safety for hypesensitivity reactions of docetaxel/hydroxypropyl-beta-cyclodextrin complex (DCX-CD) were investigated. The preparation of DCX-CD was confirmed by using differential scanning calorimetry, X-ray powder diffraction analysis, and scanning electron microscope. The anticancer activity was tested in human lung cancer A549 cell-transplanted mice and the hypersensitivity was tested in Beagle dogs after intravenous administration of DCX-CD, Taxotere, and their respective vehicles. In the hypersensitivity test, plasma histamine levels were determined using an ELISA method. Our results showed that DCX-CD was pharmacologically equivalent to Taxotere. Furthermore, DCX-CD did not cause the release of histamines or any significant symptoms associated with hypersensitivity. These results suggested that DCX-CD could be a promising alternative to Taxotere for cancer chemotherapy with reduced side effects.
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页码：355 / 361
页数：7
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